A review of fundamental principles for animal models of DOHaD research: an Australian perspective
A review of fundamental principles for animal models of DOHaD research: an Australian perspective
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DOI：
10.1017/s2040174416000477
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发表时间：
2016-10-01
影响因子：
1.7
通讯作者：
Morrison, J. L.
中科院分区：
文献类型：
--
作者：
Dickinson, H.;Moss, T. J.;Morrison, J. L.
流行病学构成了巴克假说、发展规划概念以及当今健康与疾病发展起源（DOHaD）学科的基础。动物实验提供了基本概念的证明，并不断产生有关基本机制的知识。基于 DOHaD 原则的对人类的干预将通过动物实验来进行。随着该学科知识的积累，通过对人类和其他动物的研究，基因组、环境和表观遗传学之间相互作用的复杂性已经被揭示。编程刺激的巨大本质和影响的广度正在变得众所周知。随着我们知识的积累，我们现在认识到许多变量对规划结果的影响。为了指导该领域的进一步动物研究，澳大利亚和新西兰 DOHaD 协会 (ANZ DOHaD) DOHaD 动物模型研究工作组于 2015 年 4 月在澳大利亚墨尔本举行的第二届 ANZ DOHaD 大会上召开了会议。这篇综述总结了动物研究对理解 DOHaD 的贡献，并就动物实验的设计和进行提出了建议，以最大限度地提高知识的相关性、可重复性和转化，从而改善健康和福祉。
Epidemiology formed the basis of the Barker hypothesis', the concept of developmental programming' and today's discipline of the Developmental Origins of Health and Disease (DOHaD). Animal experimentation provided proof of the underlying concepts, and continues to generate knowledge of underlying mechanisms. Interventions in humans, based on DOHaD principles, will be informed by experiments in animals. As knowledge in this discipline has accumulated, from studies of humans and other animals, the complexity of interactions between genome, environment and epigenetics, has been revealed. The vast nature of programming stimuli and breadth of effects is becoming known. As a result of our accumulating knowledge we now appreciate the impact of many variables that contribute to programmed outcomes. To guide further animal research in this field, the Australia and New Zealand DOHaD society (ANZ DOHaD) Animals Models of DOHaD Research Working Group convened at the 2nd Annual ANZ DOHaD Congress in Melbourne, Australia in April 2015. This review summarizes the contributions of animal research to the understanding of DOHaD, and makes recommendations for the design and conduct of animal experiments to maximize relevance, reproducibility and translation of knowledge into improving health and well-being.