Association of low bone mineral density with selective serotonin reuptake inhibitor use by older men
Association of low bone mineral density with selective serotonin reuptake inhibitor use by older men
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DOI：
10.1001/archinte.167.12.1246
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发表时间：
2007-06-25
影响因子：
--
通讯作者：
Bliziotes, Michael
中科院分区：
文献类型：
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作者：
Haney, Elizabeth M.;Chan, Benjamin K. S.;Bliziotes, Michael
背景：选择性5-羟色胺再摄取抑制剂(SSRI)是一类广泛使用的抗抑郁药物，可阻断5-羟色胺转运体。成骨细胞和骨细胞表达功能性的5-羟色胺转运体；5-羟色胺转运体基因在小鼠中的破坏导致骨量减少；而SSRI的使用与髋部骨折风险的增加有关。方法：为了确定SSRI的使用是否与老年男性较低的骨密度(BMD)相关，并将SSRI的结果与其他抗抑郁药物的结果进行比较，我们对参与男性骨质疏松性骨折前瞻性队列研究的5995名男性进行了横断面分析。主要观察指标包括用药情况；用双能X射线骨密度仪测量股骨颈、大转子和腰椎的骨密度；以及潜在的协变量。结果：在调整后的分析中，与未使用抗抑郁药的男性(n=5708)相比，服用SSRI的患者(n=160)的全髋部骨密度平均降低3.9%，腰椎平均骨密度降低5.9%。002为全髋关节；P
Background: Selective serotonin reuptake inhibitors (SSRIs) are a widely used class of antidepressants that block the serotonin transporter. Osteoblasts and osteocytes express functional serotonin transporters; serotonin transporter gene disruption in mice results in osteopenia; and SSRI use has been associated with increased risk of hip fracture.Methods: To determine whether SSRI use is associated with lower bone mineral density (BMD) in older men and to compare the results for SSRIs with those of other antidepressants, we performed a cross-sectional analysis of data from 5995 men 65 years and older participating in the prospective cohort Osteoporotic Fractures in Men Study. Main outcome measures included medication use; BMD at the femoral neck, greater trochanter, and lumbar spine measured by dual-energy x-ray absorptiometry; and potential covariates.Results: In adjusted analyses, mean BMD among SSRI users (n= 160) was 3.9% lower at the total hip and 5.9% lower at the lumbar spine compared with BMD in men reporting no antidepressant use (n= 5708 [P=. 002 for total hip; P