The Healing Effects of Autologous Mucosal Grafts in Experimentally Injured Rabbit Maxillary Sinuses.
The Healing Effects of Autologous Mucosal Grafts in Experimentally Injured Rabbit Maxillary Sinuses.
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DOI：
10.21053/ceo.2016.9.1.44
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发表时间：
2016-03
影响因子：
3
通讯作者：
Iseri M
中科院分区：
文献类型：
--
作者：
Topdag M;Kara A;Konuk E;Demir N;Ozturk M;Calıskan S;Topdag DO;Ulubil A;Keskin IG;Iseri M
鼻子和鼻窦的愈合过程是相当复杂的，并且知之甚少。在本研究中，我们的目的是比较粘膜自体移植物对兔上颌窦粘膜退化与伤口愈合的影响。据推测，粘膜移植物将促进纤毛发生和改善再生纤毛的形态。本研究包括10只雌性新西兰兔。他们通过经皮途径接受了上颌窦外手术。将20个上颌窦随机分为2组：“自然愈合组”和“自体移植组”。术后第14天处死动物。扫描电子显微镜（SEM）和光学显微镜用于评价。移植组的细胞组成优于自然愈合组。移植组的纤毛上皮覆盖面积较自然愈合组大，纤毛平均长度也较自然愈合组长。此外，在自然愈合组中存在较宽的纤毛和异常形态区域。我们认为，用移植物覆盖裸露区域可促进上皮再生，并可预防鼻窦手术后的早期并发症。
Healing processes of the nose and paranasal sinuses are quite complex, and poorly understood. In this study, we aimed to compare the effect of mucosal autologous grafts on the degenerated rabbit maxillary sinus mucosa with spontaneous wound healing. It is hypothesized that mucosal grafts will enhance ciliogenesis and improve the morphology of regenerated cilia. Ten female New Zealand rabbits were included in the study. They underwent external maxillary sinus surgery through a transcutaneous approach. A total of 20 maxillary sinuses were randomly divided into 2 groups: ‘spontaneous healing group’ and ‘autologous graft group.’ The animals were sacrificed at the 14th day after the surgery. Scanning electron microscope (SEM), and light microscope were used for the evaluation. Cellular composition of the graft group is better than the spontaneous healing group. The graft group had larger areas covered with ciliary epithelium than the spontaneous healing group, and the mean length of the cilias were also longer. Additionally, there were wider cilia with abnormal morphology areas in the spontaneous healing group. In our opinion, covering of the denuded areas with a graft improves re-epithelization, and may prevent the early complications after sinus surgeries.