Effects of chytridiomycosis on hematopoietic tissue in the spleen, kidney and bone marrow in three diverse amphibian species
Effects of chytridiomycosis on hematopoietic tissue in the spleen, kidney and bone marrow in three diverse amphibian species
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DOI：
10.1093/femspd/ftw069
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发表时间：
2016-10-01
影响因子：
3.3
通讯作者：
Berger, Lee
中科院分区：
文献类型：
--
作者：
Brannelly, Laura A.;Webb, Rebecca J.;Berger, Lee
两栖动物数量下降的主要原因之一是致命的真菌病原体 Batrachochytrium dendrobatidis (Bd)。对发病机制和宿主免疫的研究旨在为有针对性的保护干预措施的制定提供信息。检查全身宿主免疫反应以及体外对淋巴细胞影响的研究表明，Bd 感染会导致免疫抑制。然而，尚不清楚哪些造血组织受到影响以及这些影响在宿主物种之间是否有所不同。我们通过量化脾脏、骨髓和肾脏中造血组织的数量，研究了实验性 Bd 感染对三种不同两栖动物的影响。 Bd 感染后，肾脏中的造血组织往往会被耗尽，而脾脏似乎不受影响。高度易感物种的骨髓被耗尽，而在抵抗力更强的物种中观察到造血组织增加。我们的研究表明，物种和造血组织对Bd感染的反应不同，可能与物种对感染的易感性有关。两栖类壶菌对不同物种和白细胞形成组织的影响不同，这可能与物种易感性有关。两栖类壶菌对不同物种和白细胞形成组织的影响不同，这可能与物种有关 易感性。
One of the major causes of amphibian population decline is the deadly fungal pathogen Batrachochytrium dendrobatidis, Bd. Research on pathogenesis and host immunity aims to inform development of targeted conservation interventions. Studies examining global host immune responses as well as effects on lymphocytes in vitro suggest that Bd infection causes immunosuppression. However, it is unknown which hematopoietic tissues are affected and if these effects differ among host species. We investigated the effect of experimental Bd infection on three diverse amphibian species by quantifying the amount of hematopoietic tissue in the spleen, bone marrow and kidney. Upon Bd infection, hematopoietic tissue in the kidney tended to be depleted, while the spleen appeared unaffected. The bone marrow in highly susceptible species was depleted, whereas an increase in hematopoietic tissue was observed in the more resistant species. Our study demonstrates that species and hematopoietic tissues behave differently in response to Bd infection, and may be related to the species' susceptibility to infection.The amphibian chytrid fungus affects different species and white-blood-cell-forming tissues differently, which might be related to species susceptibility.The amphibian chytrid fungus affects different species and white-blood-cell-forming tissues differently, which might be related to species susceptibility.