REGULATION OF BLOOD-PRESSURE BY SYMPATHETIC-NERVE FIBERS AND ADRENAL-MEDULLA IN NORMOTENSIVE AND HYPERTENSIVE RATS
REGULATION OF BLOOD-PRESSURE BY SYMPATHETIC-NERVE FIBERS AND ADRENAL-MEDULLA IN NORMOTENSIVE AND HYPERTENSIVE RATS
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DOI：
10.1161/01.res.31.4.617
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发表时间：
1972-01-01
影响因子：
20.1
通讯作者：
VAN AMERINGEN, MR
中科院分区：
文献类型：
--
作者：
DE CHAMPLAIN, J;VAN AMERINGEN, MR
本文研究了正常和高血压大鼠交感神经纤维和肾上腺髓质在血压和心率调节中的作用。单独化学交感神经切除术，6-OH-DA治疗，或双侧肾上腺切除术降低血压只有轻微的血压正常的动物。在用脱氧皮质酮（DOCA）和盐水造成高血压的动物中，这些程序中的每一个都比血压正常的动物在更大程度上降低血压，但血压仍保持在高血压水平。这两种手术的结合导致血压的下降幅度大于从个体效应中预测的，这表明交感神经系统的一个组成部分的去除可以通过剩余组成部分的过度活跃来补偿。化学交感神经切除术后，肾上腺切除术产生了一个快速和显着的血压下降，在血压正常和高血压的动物和肾上腺切除术后1小时内，血压稳定在50毫米汞柱左右。由于在去除交感神经系统的两种组分后，血压正常和高血压动物的基础血压相同，这表明在用DOCA和钠处理的大鼠中解释血压升高的最可能的因素是交感神经纤维和肾上腺髓质的协同活性亢进。
The respective roles of the sympathetic nerve fibers and adrenal medulla in the regulation of blood pressure and heart rate were studied in normotensive and hypertensive rats. Chemical sympathectomy alone, by treatment with 6-OH-DA, or bilateral adrenalectomy reduced blood pressure only slightly in normotensive animals. In animals made hypertensive with deoxycorticosterone (DOCA) and saline, each of these procedures reduced blood pressure to a greater extent than in normotensive animals, but the blood pressure remained at hypertensive levels. The combination of both procedures resulted in a greater fall in blood pressure than could have been predicted from individual effects, suggesting that the removal of one component of the sympathetic system can be compensated for by a hyperactivity of the remaining component. After chemical sympathectomy, adrenalectomy produced a rapid and marked fall in blood pressure in both normotensive and hypertensive animals and the blood pressure stabilized around 50 mm Hg within 1 hour after adrenalectomy. Since the basal blood pressure was identical in normotensive and hypertensive animals after removal of both components of the sympathetic system, this suggests that the most likely factor which would account for an elevated blood pressure in rats treated with DOCA and sodium is a synergic hyperactivity of the sympathetic fibers and adrenal medulla.