Poor responsiveness to clopidogrel: Drug-specific or class-effect mechanism? - Evidence from a clopidogrel-to-ticlopidine crossover study
Poor responsiveness to clopidogrel: Drug-specific or class-effect mechanism? - Evidence from a clopidogrel-to-ticlopidine crossover study
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DOI：
10.1016/j.jacc.2007.04.092
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发表时间：
2007-09-18
影响因子：
24
通讯作者：
Ferrari, Roberto
中科院分区：
文献类型：
--
作者：
Campo, Gianluca;Valgimigli, Marco;Ferrari, Roberto
目的 本研究旨在调查氯吡格雷不良反应者在服用噻氯匹定后是否仍然如此（类别效应），或者目前可用的噻吩并吡啶类药物之间是否存在药物特异性效应。 背景 氯吡格雷不良反应者在服用噻氯匹定后是否也表现出不充分的血小板抑制作用仍不清楚。 方法 使用光透射聚集测定法对 143 名服用阿司匹林的患者进行血小板聚集 (PA) 测量二磷酸腺苷作为基线 (T-O) 和氯吡格雷稳态 (T-1) 的激动剂。 T-1后停止氯吡格雷并用噻氯匹定替代。然后在噻氯匹定稳态 (T-2) 下评估 PA。阻力定义为 T-O 和治疗后（T-1 或 T-2）PA 之间的绝对差异
Objectives This study was designed to investigate whether poor responders to thienopyridines after clopidogrel remain so even after ticlopidine administration (class effect) or whether a drug-specific effect exists between currently available thienopyridines.Background Whether clopidogrel poor responders also display inadequate platelet inhibition after ticlopidine administration remains undefined.Methods Platelet aggregation (PA) was measured in 143 patients, while they were taking aspirin, with light transmission aggregometry using adenosine diphosphate as an agonist at baseline (T-O) and at clopidogrel steady state (T-1). After T-1 clopidogrel was stopped and substituted with ticlopidine. Then PA was assessed at ticlopidine steady state (T-2). Resistance was defined as an absolute difference between T-O and after-treatment (T-1 or T-2) PA