BRADYKININ AND SEROTONIN EFFECTS ON VARIOUS TYPES OF CUTANEOUS NERVE-FIBERS
BRADYKININ AND SEROTONIN EFFECTS ON VARIOUS TYPES OF CUTANEOUS NERVE-FIBERS
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DOI：
10.1007/bf00592598
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发表时间：
1974-01-01
影响因子：
4.5
通讯作者：
HANDWERKER, HO
中科院分区：
文献类型：
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作者：
BECK, PW;HANDWERKER, HO
1.缓激肽（BKN）和5-羟色胺（5-HT）是从损伤组织产生的内源性物质，即使少量进入皮肤也会引起人和动物的疼痛反应。为了探讨哪些神经成分介导这些“局部激素”引起的感觉，我们研究了猫后肢皮神经中单个传入纤维对小剂量（5-30 μg）5-HT和BKN的峰电位反应。2.两种物质均可兴奋粗、细和无髓纤维。根据它们提供的受体类型，对纤维进行了进一步的分类。在我们测试的无髓纤维中，α 1受体类别被5-HT和BKN激活，但在有髓纤维中，只有特定的受体组被证明是反应性的，即具有细髓鞘传入的慢适应性低阈值和高阈值机械感受器以及由粗髓鞘传入提供的慢适应性机械感受器。注射后10秒，并且在不自发放电的单位中持续长达4分钟。4.以1：15分钟的低速率重复注射同一种药物可使对它的反应消失，但这种快速耐受并不减弱另一种物质的作用。这可能是BKN和5-HT作用于神经膜上不同的药理学受体的一个指示。5. BKN注射液可增强无髓伤害感受性纤维对有害辐射热刺激的锋电位放电2-5分钟。由此得出结论，该药剂可能在发炎皮肤的过敏中起作用。
1.Bradykinin (BKN) and Serotonin (5-HT) are endogeneous substances yielded from injured tissue and evoke pain reactions in man and animals when brought into the skin even in small quantities. In order to test which nervous elements mediate the sensations evoked by these “local hormones” we studied the spike responses of single afferent fibres in cutaneous nerves of the cat's hind leg upon intraarterial administration of small doses (5–30 μg) of 5-HT and BKN.2.Thick myelinated, thin myelinated, and unmyelinated fibres could be excited by both substances. A further classification of the fibres was done according to the receptor types supplied by them. Among the unmyelinated fibres we tested, al receptor classes were activated by 5-HT and BKN, but among the myelinated fibres only definite groups of receptors proved to be responsive, i.e. the slowly adapting low and high threshold mechanoreceptors with thin myelinated afferents and the slowly adapting mechanoreceptors supplied by thick myelinated fibres.3.The spike responses started 10–2- sec after injection and persisted up to 4 min in units not firing spontaneously. Discharge frequencies usually were much lower than upon physical stimulation of the receptors.4.Repeated injection of the same agent at a rate as low as 1:15 min abolished the response to it. However this tachyphylaxis was found not to diminish the effect of the other substance. This might be an indication of an action of BKN and 5-HT on different pharmacological receptors on the nervous membranes.5.BKN injections were found to enhance the spike discharges of unmyelinated nocipeptive fibres upon noxious radiant heat stimulation for a period of 2–5 min after a single injection of 5–30 μg. It was concluded therefrom that this agent might play a role in the hyperpathia of inflamed skin.