Smoking cessation, lung function, and weight gain:: a follow-up study
Smoking cessation, lung function, and weight gain:: a follow-up study
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DOI：
10.1016/s0140-6736(05)66511-7
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发表时间：
2005-05-07
期刊：
影响因子：
168.9
通讯作者：
Burney, P
中科院分区：
文献类型：
--
作者：
Chinn, S;Jarvis, D;Burney, P
只有一个国家的一项基于人群的研究报告了戒烟和体重变化对肺功能的影响，没有一项报告了净效应。我们估计戒烟的净效益，吸烟和体重变化的独立影响，在国际欧洲共同体呼吸系统健康Survey.Methods 6654参与者在27个中心的变化，在1991-93年，年龄20-44岁时，肺功能测定，并在1998-2002年的呼吸功能。吸烟信息从详细的问卷调查中获得。肺功能的变化进行了分析，吸烟和体重的变化，调整年龄和身高，在男性和女性单独和共同的相互作用terms.Findings相比，那些从来没有吸烟，在FEV 1下降较低的男性持续戒烟者（平均差异5.4 mL/年，95% CI 1.7 - 9.1）和两次调查之间戒烟者（2.5 mL，-1.9至7.0），吸烟者（-4.8 mL，-7.9至-1.6）更高。在女性中，估计值分别为每年1.3 mL（-1.5至4.1）、2.8 mL（-0.8至6.3）和-5.1 mL（-7.5至2.8）。这些性别差异不显著。男性每增加1公斤体重，FEV 1变化-11.5毫升（-13.3到-9.6），女性每增加1公斤体重，FEV 1变化-3.7毫升（-5.0到-2.5），这使得男性戒烟的益处减少了38%，女性减少了17%。
Background Only one population-based study in one country has reported effects of smoking cessation and weight change on lung function, and none has reported the net effect. We estimated the net benefit of smoking cessation, and the independent effects of smoking and weight change on change in ventilatory lung function in the international European Community Respiratory Health Survey.Methods 6654 participants in 27 centres had lung function measured in 1991-93, when aged 20-44 years, and in 1998-2002. Smoking information was obtained from detailed questionnaires. Changes in lung function were analysed by change in smoking and weight, adjusted for age and height, in men and women separately and together with interaction terms.Findings Compared with those who had never smoked, decline in FEV1 was lower in male sustained quitters (mean difference 5.4 mL per year, 95% CI 1.7 to 9.1) and those who quit between surveys (2.5 mL, -1.9 to 7.0), and greater in smokers (-4.8 mL, -7.9 to -1.6). In women, estimates were 1.3 mL per year (-1.5 to 4.1), 2.8 mL (-0.8 to 6.3) and -5.1 mL (-7.5 to -2.8), respectively.. These sex differences were not significant. FEV1 changed by -11.5 mL (-13.3 to -9.6) per kg weight gained in men, and by -3.7 mL per kg (-5.0 to -2.5) in women, which diminished the benefit of quitting by 38% in men, and by 17% in women.Interpretation Smoking cessation is beneficial for lung function, but maximum benefit needs control of weight gain, especially in men.