CSF-hypocretin-1 levels in patients with major depressive disorder compared to healthy controls
CSF-hypocretin-1 levels in patients with major depressive disorder compared to healthy controls
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DOI：
10.1016/j.psychres.2011.06.004
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发表时间：
2011-12-30
影响因子：
11.3
通讯作者：
Schoenknecht, Peter
中科院分区：
文献类型：
--
作者：
Schmidt, Frank Martin;Arendt, Elisabeth;Schoenknecht, Peter
抑郁症患者表现出觉醒调节受损、过度警觉和烦躁的症状，以及难以入睡和保持睡眠连续性的症状。下丘脑分泌素 (hcrt) 水平的变化作为影响觉醒和睡眠-觉醒调节的多肽，已在情感障碍中进行了讨论，但尚未在单纯单相抑郁患者与健康对照者中进行研究。在本研究中，首次分析了没有精神合并症的重度抑郁症（MDD）患者的脑脊液（CSF）hcrt-1水平，并与健康对照的水平进行了比较。 17 名 MDD 住院患者（平均汉密尔顿抑郁量表 13.9 +/- 7.4）和 10 名健康对照者。使用荧光免疫分析 (FIA) 测量 CSF-hcrt-1 水平。 MDD 患者的平均 hcrt-1 CSF 水平 (74.3 +/- 17.8 pg/ml) 与健康对照 (82.8 +/- 22.1 pg/ml) 相比没有差异。 Hcrt-1 水平与抑郁发作的严重程度、抑郁症状或发作次数无关。尽管过度觉醒的自主神经和神经体液症状在 MDD 中很常见，但与健康对照相比，MDD 中脑脊液中的 hcrt-1 水平并未发生改变。在表现出警惕性调节受损的抑郁症患者中，hcrt-1 水平是否发生改变，必须在进一步的研究中结合 CSF-hcrt-1 测量与脑电图进行研究。 (C) 2011 Elsevier Ireland Ltd. 保留所有权利。
Depressive patients exhibit symptoms of impaired regulation of wakefulness with hyperarousal and agitation as well as difficulties to falling asleep and preserving sleep continuity. Changes in hypocretin (hcrt) levels as polypeptides with impact on arousal and sleep-wake-regulation have been discussed in affective disorders but have not been investigated in patients with solely unipolar depression in comparison to healthy controls. In the present study, cerebrospinal fluid (CSF) levels of hcrt-1 for the first time were analyzed in patients with major depressive disorder (MDD) without psychiatric comorbidities and compared with levels in healthy controls. In 17 inpatients with MDD (mean Hamilton Depression Rating Scale 13.9 +/- 7.4) and 10 healthy controls. CSF-hcrt-1 levels were measured using a fluorescence immunoassay (FIA). The mean hcrt-1 CSF levels in patients with MDD (74.3 +/- 17.8 pg/ml) did not differ compared to that of healthy controls (82.8 +/- 22.1 pg/ml). Hcrt-1 levels did not correlate with the severity of depressive episode, the symptoms of depression or the number of episodes. Although autonomic and neurohumoral signs of hyperarousal are common in MDD, hcrt-1 levels in CSF were not found to be altered in MDD compared to healthy controls. Whether hcrt-1 levels are altered in depressive patients exhibiting impaired vigilance regulation has to be investigated in further studies combining measures of CSF-hcrt-1 with electroencephalography. (C) 2011 Elsevier Ireland Ltd. All rights reserved.