Quality of life and survival in patients with heart failure
Quality of life and survival in patients with heart failure
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DOI：
10.1093/eurjhf/hfs148
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发表时间：
2013-01-01
影响因子：
18.2
通讯作者：
Lesman-Leegte, Ivonne
中科院分区：
文献类型：
--
作者：
Hoekstra, Tialda;Jaarsma, Tiny;Lesman-Leegte, Ivonne
为了研究自测疾病特异性和一般生活质量是否能预测长期死亡率，而不依赖于脑钠肽（BNP）水平，并探讨明确定义的心力衰竭（HF）人群中生活质量低的相关因素，对661例患者（62例男性;年龄71岁;左心室射血分数34）进行前瞻性随访3年。在因HF入院后出院时评估生活质量问卷（生活阶梯、RAND 36和明尼苏达心力衰竭生活问卷）和BNP水平。三年死亡率为42。调整人口统计学变量、临床变量和BNP水平后，生活质量评分较差预测死亡率较高;在RAND的身体功能[风险比（HR）1.08，95置信区间（CI）1.021.14]和一般健康（HR 1.08，95 CI 1.011.16）维度上，每10个单位死亡率较高36。这些维度得分低的患者更可能属于纽约心脏协会IIIIV级，诊断为合并症，患有HF的时间较长，估计肾小球滤过率较低，β受体阻滞剂处方较少。
To examine whether self-rated disease-specific and generic quality of life predicts long-term mortality, independent of brain natriuretic peptide (BNP) levels, and to explore factors related to low quality of life in a well-defined heart failure (HF) population.A cohort of 661 patients (62 male; age 71 years; left ventricular ejection fraction 34) was followed prospectively for 3 years. Quality of life questionnaires (Ladder of Life, RAND36, and Minnesota Living with Heart Failure Questionnaire) and BNP levels were assessed at discharge after a hospital admission for HF. Three-year mortality was 42. After adjustment for demographic variables, clinical variables, and BNP levels, poor quality of life scores predicted higher mortality; per 10 units on the physical functioning [hazard ratio (HR) 1.08, 95 confidence interval (CI) 1.021.14] and general health (HR 1.08, 95 CI 1.011.16) dimensions of the RAND36. Patients with low scores on these dimensions were more likely to be in New York Heart Association class IIIIV, diagnosed with co-morbidities, have suffered longer from HF, have lower estimated glomerular filtration rates, and have fewer beta-blocker prescriptions.Quality of life was independently related to survival in a cohort of hospitalized patients with HF.NCT 98675639.