Natural killer cell activity in patients with hepatocellular carcinoma relative to early development and tumor invasion
Natural killer cell activity in patients with hepatocellular carcinoma relative to early development and tumor invasion
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DOI：
10.1002/1097-0142(19900215)65:4
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发表时间：
1990-02
期刊：
影响因子：
6.2
通讯作者：
W. Chuang;Hong-Wen Liu;W. Chang
中科院分区：
文献类型：
--
作者：
W. Chuang;Hong-Wen Liu;W. Chang
为探讨自然杀伤（NK）细胞活性在肝癌（HCC）患者临床评估中的意义，对32例肝硬化（LC）合并HCC患者和29例LC患者进行了研究。与对照组比较，肝癌组和肝硬化组NK细胞活性均明显降低，但肝癌组与肝硬化组之间无统计学差异。肝癌患者NK细胞活性的降低与患者年龄呈负相关，有静脉侵犯或两叶均受累的肝癌患者NK细胞活性较低。提示肝癌患者NK细胞活性的降低可能与并存的肝脏疾病有关，NK细胞活性的显著降低可能是肝癌早期发生和侵袭的原因之一。
To evaluate the significance of natural killer (NK) cell activity in the clinical assessment of patients with hepatocellular carcinoma (HCC), 32 patients combined with liver cirrhosis (LC) and HCC, and 29 LC patients were studied. The NK cell activity was markedly decreased in HCC patients and the LC group as compared with the control group, but there was no statistical difference between the NK cell activity of the HCC group and the LC group. The depression of NK cell activity in HCC patients was inversely correlated with the patient's age, and the HCC patients with venous invasion or with both lobes involved had lower NK cell activity. These results suggest that the decreased NK cell activity in HCC patients might be related to the coexistent liver disease, and marked decrease in NK cell activity might be one of the causes for the early development and invasion of HCC.