Chronic In Vivo Evaluation of PEDOT/CNT for Stable Neural Recordings.
Chronic In Vivo Evaluation of PEDOT/CNT for Stable Neural Recordings.
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DOI：
10.1109/tbme.2015.2445713
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发表时间：
2016-01
期刊：
影响因子：
--
通讯作者：
Cui XT
中科院分区：
文献类型：
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作者：
Kozai TD;Catt K;Du Z;Na K;Srivannavit O;Haque RU;Seymour J;Wise KD;Yoon E;Cui XT
亚细胞大小的长期植入记录电极已经证明了在更大的记录探针的单单位（SU）产量的显着改善。其他工作通过将亚细胞纤维状晶格结构与硅微制造的设计空间多功能性相结合来扩展这一初步成功，以进一步提高信噪比，电极密度和记录单元的稳定性数月至数年。然而，超小微电极呈现非常高的阻抗，其必须被降低以用于SU记录。虽然掺杂有聚苯乙烯磺酸盐（PSS）涂层的聚（3，4-乙撑二氧噻吩）（PEDOT）在降低电极阻抗的急性至早期-慢性研究中已经证明了巨大的成功，但存在对长期稳定性的担忧。在这里，我们展示了一种新的共混物的PEDOT掺杂羧基官能化的多壁碳纳米管（CNT），这表明显着改善了传统的PEDOT/PSS公式。利用已有的方法制备了点阵式亚细胞电极阵列。将PEDOT与羧酸官能化的碳纳米管聚合到高阻抗（8.0±0.1 MΩ：M±S.E.）250 µm2黄金记录点。与PEDOT/PSS记录位点相比，PEDOT/CNT涂覆的亚细胞电极在四个月内表现出慢性尖峰记录稳定性的显著改善。这些结果证明了亚细胞大小的记录和刺激电极和长期稳定性的巨大前景。该项目使用领先的生物材料来开发慢性神经探针，这些探针很小（亚细胞），具有良好的电性能，可进行稳定的长期记录。高密度超小电极与先进的电极表面改性相结合，可能会对长期（永久），高质量和选择性神经接口的发展做出重大贡献。
Sub-cellular sized chronically implanted recording electrodes have demonstrated significant improvement in single-unit (SU) yield over larger recording probes. Additional work expands on this initial success by combining the subcellular fiber-like lattice structures with the design space versatility of silicon microfabrication to further improve the signal-to-noise ratio, density of electrodes, and stability of recorded units over months to years. However, ultra-small microelectrodes present very high impedance, which must be lowered for SU recordings. While poly(3,4-ethylenedioxythiophene) (PEDOT) doped with polystyrene sulfonate (PSS) coating has demonstrated great success in acute to early-chronic studies for lowering the electrode impedance, concern exists over long-term stability. Here, we demonstrate a new blend of PEDOT doped with carboxyl functionalized multi-walled carbon nanotubes (CNTs) which shows dramatic improvement over the traditional PEDOT/PSS formula. Lattice style subcellular electrode arrays were fabricated using previously established method. PEDOT was polymerized with carboxylic acid functionalized carbon nanotubes onto high impedance (8.0±0.1 MΩ: M±S.E.) 250 µm2 gold recording sites. PEDOT/CNT coated subcellular electrodes demonstrated significant improvement in chronic spike recording stability over four months compared to PEDOT/PSS recording sites. These results demonstrate great promise for subcellular sized recording and stimulation electrodes and long-term stability. This project uses leading-edge biomaterials to develop chronic neural probes that are small (sub-cellular) with excellent electrical properties for stable long-term recordings. High density ultrasmall electrodes combined with advanced electrode surface modification are likely to make significant contributions to the development of long-term (permanent), high quality, and selective neural interfaces.