Characterization of larval growth in C. elegans cuticle mutants.
Characterization of larval growth in C. elegans cuticle mutants.
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DOI：
10.17912/micropub.biology.000662
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发表时间：
2022
影响因子：
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通讯作者：
Andersen, Erik C
中科院分区：
文献类型：
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作者：
Nyaanga, Joy;Shirman, Sasha;Mangan, Niall M;Andersen, Erik C
在秀丽隐杆线虫中，许多参与角质层形成的基因也被认为会影响身体的大小和形状。我们评估了长线虫和短线虫体型突变体从 L1 到 L4 阶段的胚胎后生长。我们发现 N2 和 lon-3 动物有相似的发育轨迹。相比之下，我们观察到与 N2 相比，测试的 dpy 突变体的体长总体减小，体宽总体增加，这与 Dpy 表型一致。我们进一步表明，突变株中动物形状的动态与先前提出的“担架”生长模型一致。
In Caenorhabditis elegans, many genes involved in the formation of the cuticle are also known to influence body size and shape. We assessed post-embryonic growth of both long and short C. elegans body size mutants from the L1 to L4 stage. We found similar developmental trajectories of N2 and lon-3 animals. By contrast, we observed overall decreases in body length and increases in body width of tested dpy mutants compared to N2, consistent with the Dpy phenotype. We further show that the dynamics of animal shape in the mutant strains are consistent with a previously proposed “Stretcher” growth model.