Proximal CA1 20-40 Hz power dynamics reflect trial-specific information processing supporting nonspatial sequence memory.
Proximal CA1 20-40 Hz power dynamics reflect trial-specific information processing supporting nonspatial sequence memory.
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DOI：
10.7554/elife.55528
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发表时间：
2022-05-09
期刊：
影响因子：
7.7
通讯作者：
Fortin, Norbert J.
中科院分区：
文献类型：
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作者：
Gattas, Sandra;Elias, Gabriel A.;Janecek, John;Yassa, Michael A.;Fortin, Norbert J.
众所周知，海马体在处理有关时间背景的信息方面发挥着关键作用。然而，目前还不清楚海马振荡是如何参与的，以及连接梯度如何影响它们的功能组织。当大鼠进行非空间气味序列记忆任务时，我们检测了CA1的局部场电位活动。我们发现，气味序列处理时期与轨道跑步时期相比，具有不同的光谱特征和近远端CA1的theta和20-40赫兹功率梯度。我们还发现，20-40赫兹的功率可以预测序列记忆的表现，特别是在CA1近端和在实验中观察到的高功率的平台期，在这些试验中，动物必须保持他们的决定，直到被指示做出反应。总之，这些结果提供了证据，证明20-40赫兹功率沿CA1轴的动力学与对顺序判断至关重要的非空间信息的试-特异性加工有关，并且与20-40赫兹功率在门控信息加工中的作用一致。
The hippocampus is known to play a critical role in processing information about temporal context. However, it remains unclear how hippocampal oscillations are involved, and how their functional organization is influenced by connectivity gradients. We examined local field potential activity in CA1 as rats performed a nonspatial odor sequence memory task. We found that odor sequence processing epochs were characterized by distinct spectral profiles and proximodistal CA1 gradients of theta and 20–40 Hz power than track running epochs. We also discovered that 20–40 Hz power was predictive of sequence memory performance, particularly in proximal CA1 and during the plateau of high power observed in trials in which animals had to maintain their decision until instructed to respond. Altogether, these results provide evidence that dynamics of 20–40 Hz power along the CA1 axis are linked to trial-specific processing of nonspatial information critical to order judgments and are consistent with a role for 20–40 Hz power in gating information processing.