EVIDENCE FOR SALTATORY CONDUCTION IN PERIPHERAL MYELINATED NERVE FIBRES
EVIDENCE FOR SALTATORY CONDUCTION IN PERIPHERAL MYELINATED NERVE FIBRES
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DOI：
10.1113/jphysiol.1949.sp004335
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发表时间：
1949-01-01
影响因子：
5.5
通讯作者：
STAMPFLI, R
中科院分区：
文献类型：
--
作者：
HUXLEY, AF;STAMPFLI, R
使用 Rana esculenta 和 R. temporaria 的坐骨神经，记录脉冲通过期间外部液体中的纵向电流。发现纵向作用电流的传导时间在每个节间实际上是恒定的，并且随着通过朗飞的每个节点而增加。振幅从每个节间的近端到远端稳定减小，但随着每个节的通过而突然增大。在每个节点处，正电流在电势变化达到最大值之前开始进入轴圆柱体。结论是产生动作电位的过程发生在朗飞结处，证实了跳跃传导理论。由于相邻节点之间外部电阻的增加，传导被可逆地阻断。结论是，每个节点的动作电位通过在轴圆柱体中向前流动并在髓鞘外的流体中返回的电流来激发下一个节点。
Using the sciatic nerve of Rana esculenta and R. temporaria, recordings were made of the longitudinal current in the external fluid during the passage of an impulse. The conduction time of the longitudinal action current was found to be practically constant at each internode and to increase as each node of Ranvier was passed. The amplitude decreased steadily from the proximal to the distal end of each internode but suddenly increased as each node was passed. At each node positive current began to enter the axis cylinder before potential change reached a maximum. It was concluded that the process which gave rise to the action potential took place at the node of Ranvier, confirming the theory of saltatory conduction. Conduction was blocked reversibly by increased external resistance between adjacent nodes. It was concluded that the action potential at each node excited the next node by current flowing forward in the axis cylinder and back in the fluid outside the myelin sheath.