Rh(III)-Catalyzed C-H Activation/[3 + 2] Annulation of N-Phenoxyacetamides via Carbooxygenation of 1,3-Dienes.
Rh(III)-Catalyzed C-H Activation/[3 + 2] Annulation of N-Phenoxyacetamides via Carbooxygenation of 1,3-Dienes.
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DOI：
10.1021/acs.orglett.1c00945
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发表时间：
2021-04
期刊：
影响因子：
5.2
通讯作者：
Liexin Wu;Liping Li;Haiman Zhang;Hui Gao;Zhi Zhou;Wei Yi
中科院分区：
文献类型：
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作者：
Liexin Wu;Liping Li;Haiman Zhang;Hui Gao;Zhi Zhou;Wei Yi
在Rh（III）催化下，N-苯氧基乙酰胺的C-H活化/[3 + 2]成环反应被用于1，3-二烯碳氧合反应，合成了二氢苯并呋喃。这种转化具有氧化还原中性过程，具有特定的化学选择性，良好的底物/官能团相容性和深刻的合成潜力。还成功地进行了实现其不对称合成的初步探索，进一步增强了该方法的实用性。
A unique Rh(III)-catalyzed C-H activation/[3 + 2] annulation of N-phenoxyacetamides has been developed for the construction of dihydrobenzofurans via carbooxygenation of 1,3-dienes. This transformation features a redox-neutral process with specific chemoselectivity, good substrate/functional group compatibility, and profound synthetic potentials. A preliminary exploration to realize their asymmetric synthesis have been also successfully demonstrated, which further strengthens the practicality of this approach.