Antioxidant Properties and UV Absorbance Pattern of Mycosporine-Like Amino Acids Analogs Synthesized in an Environmentally Friendly Manner
Antioxidant Properties and UV Absorbance Pattern of Mycosporine-Like Amino Acids Analogs Synthesized in an Environmentally Friendly Manner
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DOI：
10.1002/jbt.21489
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发表时间：
2013-06-01
影响因子：
3.6
通讯作者：
Colepicolo, Pio
中科院分区：
文献类型：
--
作者：
Andreguetti, Daniel;Stein, Erika M.;Colepicolo, Pio
本研究报道了一种高效、清洁的制备类霉孢菌素氨基酸（MMAs）类似物的方法，并对其紫外吸收特性和抗氧化活性进行了评价。记录化合物的紫外辐射吸收模式，然后用于定义它们的摩尔吸光系数。采用1，1-二苯基-2-苦基肼（DPPH）自由基清除试验和超氧阴离子自由基清除试验评价其抗氧化活性。九种化合物中有八种显示出对超氧自由基的良好活性，因为只有一种类似物在DPPH测定中表现出可测量的IC 50。(c)2013 Wiley Periodicals，Inc. J BiochemMol Toxicol 27：305-312，2013;在wileyonlinelibrary.com在线查看这篇文章。DOI 10.1002/jbt.21489
In current study, we report efficient and clean procedure for preparing mycosporine-like amino acids (MMAs) analogs and evaluate their ultraviolet absorbance properties and antioxidant activities. The ultraviolet radiation absorbance patterns of the compounds were recorded and then used to define their molar absorptivities. The antioxidant activities were assessed using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging and superoxide radical scavenging assays. Eight of nine compounds showed good activity against superoxide radicals, as only one of the analogs exhibited a measurable IC50 in the DPPH assay. (c) 2013 Wiley Periodicals, Inc. J BiochemMol Toxicol 27:305-312, 2013; View this article online at wileyonlinelibrary.com. DOI 10.1002/jbt.21489