SIRT2 polymorphism rs10410544 is associated with Alzheimer's disease in a Han Chinese population
SIRT2 polymorphism rs10410544 is associated with Alzheimer's disease in a Han Chinese population
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DOI：
10.1016/j.jns.2013.10.001
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发表时间：
2014-01-15
影响因子：
4.4
通讯作者：
Tan, Lan
中科院分区：
文献类型：
--
作者：
Xia, Man;Yu, Jin-Tai;Tan, Lan
Sirtuin 2 (SIRT2) 是一种强蛋白脱乙酰酶，在中枢神经系统中高表达。最近，在 APOE epsilon 4 阴性的白种人群体中发现了 SIR 12 rs10410544 多态性与迟发性阿尔茨海默病 (LOAD) 之间的关联。为了调查 SIRT2 rs10410544 UT 多态性与 LOAD 风险之间的潜在关联，我们在北方汉族人群中进行了一项独立的复制病例对照研究，其中包括 1133 例病例和 1159 名年龄和性别匹配的健康对照。结果显示，LOAD病例和对照之间的基因型和等位基因频率存在显着差异（基因型P = 0.008，等位基因P = 0.009）。与 C 等位基因相比，rs10410544 的 T 等位基因发生 LOAD 的风险是 C 等位基因的 1.709 倍。根据载脂蛋白 E (APOE)ε 4 携带状态进行分层后，只有 APOE epsilon 4 非携带者（P = 0.035，调整后 OR = 1.656，95% CI：1.036-2.647）显示 LOAD 和 SIRT2 rs10410544 T 等位基因之间的关系。本研究提供了证据，证明 SIRT2 的 rs10410544 C/T 多态性与中国北方汉族人群对 LOAD 的遗传易感性相关。 (C) 2013 Elsevier B.V. 保留所有权利。
Sirtuin 2 (SIRT2) is a strong protein deacetylase, which is highly expressed in central nervous system. Recently, an association between SIR 12 rs10410544 polymorphism and late-onset Alzheimer's disease (LOAD) was found in the APOE epsilon 4-negative Caucasian population. To investigate the potential association between the rs10410544 UT polymorphism of SIRT2 and the risk of LOAD, we conducted an independent replication case-control study in a Northern Han Chinese population comprising 1133 cases and 1159 healthy controls being matched for age and gender. The results revealed that there were significant differences in genotype and allele frequencies between LOAD cases and controls (genotype P = 0.008, allele P = 0.009). When compared with the C allele, the T allele of rs10410544 demonstrated a 1.709-fold risk for developing LOAD. After stratification by apolipoprotein E (APOE)epsilon 4-carrying status, only APOE epsilon 4 noncarriers (P = 0.035, adjusted OR = 1.656, 95% CI: 1.036-2.647) showed the relation between LOAD and SIRT2 rs10410544 T allele. This study provides the evidence that the rs10410544 C/T polymorphism of SIRT2 was associated with genetic susceptibility to LOAD in a Northern Han Chinese population. (C) 2013 Elsevier B.V. All rights reserved.