Lymphangiogenesis in development and disease
Lymphangiogenesis in development and disease
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DOI：
10.1160/th07-04-0238
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发表时间：
2007-08-01
影响因子：
6.7
通讯作者：
Detmar, Michael
中科院分区：
文献类型：
--
作者：
Liersch, Ruediger;Detmar, Michael
淋巴管系统在维持体液平衡、传入性免疫反应、肠道脂质摄取和恶性细胞的转移等方面发挥着重要作用。近年来，淋巴管内皮细胞特异性标志物和生长因子的发现以及淋巴管功能受损小鼠遗传模型的建立，为淋巴系统的生理学和胚胎发育的分子调控提供了新的视角。他们还确定了突变失活导致人类淋巴水肿相关疾病的分子途径。此外，淋巴系统在慢性炎症性疾病和移植排斥反应中起着重要作用。重要的是，恶性肿瘤可以直接促进原发肿瘤内和引流淋巴结内的淋巴管生成，导致癌症转移到淋巴结和以外的地方。基于这些发现，目前正在开发新的治疗策略，旨在抑制或促进疾病中淋巴管的形成和功能。
The lymphatic vascular system plays an important role in the maintenance of fluid homeostasis, in the afferent immune response, in the intestinal lipid uptake and in the metastatic spread of malignant cells. The recent discovery of specific markers and growth factors for lymphatic endothelium and the establishment of genetic mouse models with impairment of lymphatic function have provided novel insights into the molecular control of the lymphatic system in physiology and in embryonic development. They have also identified molecular pathways whose mutational inactivation leads to human diseases associated with lymphedema. Moreover, the lymphatic system plays a major role in chronic inflammatory diseases and in transplant rejection. Importantly, malignant tumors can directly promote lymphangio-genesis within the primary tumor and in draining lymph nodes, leading to enhanced cancer metastasis to lymph nodes and beyond. Based upon these findings, novel therapeutic strategies are currently being developed that aim at inhibiting or promoting the formation and function of lymphatic vessels in disease.