DNA Methylation in Memory Formation: Emerging Insights.
DNA Methylation in Memory Formation: Emerging Insights.
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DOI：
10.1177/1073858415579635
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发表时间：
2015-10
期刊：
影响因子：
--
通讯作者：
Sweatt JD
中科院分区：
文献类型：
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作者：
Heyward FD;Sweatt JD
突触可塑性和长期记忆的建立需要持久的细胞和分子修饰，尽管其组成部分的快速更替，但作为一个整体，这些修饰必须持久。这样的分子壮举必须由一个稳定的、自我延续的细胞信息存储机制来介导。DNA甲基化是典型的细胞信息储存机制，被认为是中枢神经系统（CNS）内稳定的活性依赖性转录改变所必需的。这篇综述详细介绍了基因靶向和全基因组测序的基础发现，这些研究成功地使我们注意到DNA甲基化是CNS内活动和经验依赖性转录改变的主要调节因子。我们提出了一个假设框架，通过该框架，可以解决涉及DNA甲基化的不同操纵及其对记忆的影响的不同实验结果，同时考虑到DNA甲基化中活动依赖性改变可能对记忆促进和记忆的独特影响。抑制基因表达。最后，我们讨论了未来研究DNA甲基化在远程记忆形成过程中的作用的潜在途径。
The establishment of synaptic plasticity and long-term memory requires lasting cellular and molecular modifications that, as a whole, must endure despite the rapid turnover of their constituent parts. Such a molecular feat must be mediated by a stable, self-perpetuating, cellular information storage mechanism. DNA methylation, being the archetypal cellular information storage mechanism, has been heavily implicated as being necessary for stable activity-dependent transcriptional alterations within the central nervous system (CNS). This review details the foundational discoveries from both gene-targeted, as well as whole-genome sequencing, studies that have successfully brought DNA methylation to our attention as a chief regulator of activity- and experience-dependent transcriptional alterations within the CNS. We present a hypothetical framework with which the disparate experimental findings dealing with distinct manipulations of the DNA methylation, and their effect on memory, might be resolved while taking into account the unique impact activity-dependent alterations in DNA methylation potentially have on both memory promoting and memory-suppressing gene expression. And last, we discuss potential avenues for future inquiry into the role of DNA methylation during remote memory formation.