Post-stroke infection: a role for IL-1ra?
Post-stroke infection: a role for IL-1ra?
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DOI：
10.1007/s12028-010-9490-7
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发表时间：
2011-04
影响因子：
3.5
通讯作者：
Becker, Kyra
中科院分区：
文献类型：
--
作者：
Tanzi, Pat;Cain, Kevin;Kalil, Angela;Zierath, Dannielle;Savos, Anna;Gee, J. Michael;Shibata, Dean;Hadwin, Jessica;Carter, Kelly;Becker, Kyra
感染是中风后常见的并发症，并且与更差的预后独立相关。临床研究表明，感染更频繁地发生在那些中风引起的免疫功能障碍的个体中。本研究旨在探讨免疫调节细胞因子和激素对淋巴细胞功能和感染风险的贡献。患者（N = 112）在缺血性卒中发作后尽快入组。在中风发作后72小时抽血评估血浆皮质醇、IL-10、IL-1 ra、淋巴细胞数量和淋巴细胞功能;在中风发作后21天内审查感染。25%的患者发生感染。卒中严重程度是感染风险的最重要预测因素。卒中发作后72小时血浆皮质醇、IL-10和IL-1 ra升高以及淋巴细胞数量减少与随后感染的风险相关。在控制中风严重程度后，只有IL-1 ra与感染风险独立相关，并且在整个中风后时期，风险程度是一致的。感染，而不是IL-1 ra本身，与3个月时的不良结局相关。在该研究队列中，血浆IL-1 ra升高与卒中后感染风险独立相关。需要进一步的研究来验证这一发现，这可能对中风治疗有重要意义。
Infection is common following stroke and is independently associated with worse outcome. Clinical studies suggest that infections occur more frequently in those individuals with stroke-induced immunologic dys-function. This study sought to explore the contribution of immunomodulatory cytokines and hormones to lymphocyte function and infection risk. Patients (N = 112) were enrolled as soon as possible after the onset of ischemic stroke. Blood was drawn to assess plasma cortisol, IL-10, IL-1ra, lymphocyte numbers, and lymphocyte function at 72 h after stroke onset; infections were censored through 21 days after stroke onset. Infection occurred in 25% of patients. Stroke severity was the most important predictor of infection risk. Increased plasma cortisol, IL-10, and IL-1ra, as well as decreased lymphocyte numbers, at 72 h after stroke onset were associated with risk of subsequent infection. After controlling for stroke severity, only IL-1ra was independently associated with infection risk, and the degree of risk was consistent throughout the post-stroke period. Infection, but not IL-1ra itself, was associated with worse outcome at 3 months. In this study cohort, increased plasma IL-1ra was independently associated with the risk of post-stroke infection. Further studies are needed to validate this finding, which could have important implications for stroke therapy.
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影响因子：
3.7
作者：
Vogelgesang A;May VE;Grunwald U;Bakkeboe M;Langner S;Wallaschofski H;Kessler C;Bröker BM;Dressel A
通讯作者：
Dressel A
影响因子：
2.6
作者：
Emsley HC;Smith CJ;Gavin CM;Georgiou RF;Vail A;Barberan EM;Illingworth K;Scarth S;Wickramasinghe V;Hoadley ME;Rothwell NJ;Tyrrell PJ;Hopkins SJ
通讯作者：
Hopkins SJ
DOI：
10.1084/jem.20021098
发表时间：
2003-09-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Prass K;Meisel C;Höflich C;Braun J;Halle E;Wolf T;Ruscher K;Victorov IV;Priller J;Dirnagl U;Volk HD;Meisel A
通讯作者：
Meisel A
影响因子：
8.3
作者：
Hug, Andreas;Dalpke, Alexander;Veltkamp, Roland
通讯作者：
Veltkamp, Roland
影响因子：
2.9
作者：
Haeusler, Karl Georg;Schmidt, Wolf U. H.;Volk, Hans-Dieter
通讯作者：
Volk, Hans-Dieter