TGF-β3-induced miR-494 inhibits macrophage polarization via suppressing PGE2 secretion in mesenchymal stem cells.
TGF-β3-induced miR-494 inhibits macrophage polarization via suppressing PGE2 secretion in mesenchymal stem cells.
复制标题
TGF-β3 诱导的miR-494 通过抑制间充质干细胞中的PGE2 分泌来抑制巨噬细胞极化。
DOI：
10.1002/1873-3468.12200
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Yayi Hou
中科院分区：
文献类型：
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作者：
Guangfeng Zhao;Huishuang Miao;Xiujun Li;Shiwen Chen;Yali Hu;Zhiqun Wang;Yayi Hou
Abnormal macrophage polarization at the maternal–fetal interface may contribute to the development of Preeclampsia (PE). The reason why macrophage polarization changed in PE is still unclear. Decidual mesenchymal stem cells (dMSCs) could regulate macrophage polarization. However, miRNA in dMSCs of PE were maladjusted. Therefore, we speculated that miRNA may affect dMSC‐regulated macrophage polarization. In this study, we found that miR‐494‐overexpressed dMSCs inhibit M2 macrophage polarization and this inhibitory effect is mediated by miR‐494‐reduced PGE2 secretion. Furthermore, we proved that miR‐494 is induced by TGF‐β3. In summary, our findings suggest that the high expression of TGF‐β3 in PE decidua stimulates miR‐494 in dMSCs and attenuates the regulation of MSC switching the macrophage toward M2 type, contributing to an immune imbalance at maternal–fetal interface.
