Metabolic Journey to Healthy Longevity
Metabolic Journey to Healthy Longevity
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DOI：
10.1159/000178032
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发表时间：
2009-01-01
期刊：
影响因子：
--
通讯作者：
Paolisso, Giuseppe
中科院分区：
文献类型：
--
作者：
Barbieri, Michelangela;Boccardi, Virginia;Paolisso, Giuseppe
背景：衰老过程与渐进性重塑有关。年龄依赖性的重塑过程主要影响人体测量和内分泌功能，进而影响代谢因素。在一些个体中，例如，非常精选的健康百岁老人群体，重塑过程是成功的。百岁老人能够达到人类寿命极限的原因在很大程度上仍不清楚；然而，对人类的几项研究表明，长寿与葡萄糖处理能力的显著改善有关--主要是胰岛素敏感度的提高和血浆胰岛素样生长因子I水平的下降。结论：限制热量摄入似乎是延年益寿的最好的正向代谢调节剂。其他特定的代谢适应，即使是那些由基因诱导的，也可能在百岁老人的健康中发挥作用。版权所有(C)2009 S.Karger AG，巴塞尔
Background: The process of aging is associated with progressive remodeling. The age-dependent remodeling process mainly affects anthropometrics and endocrine function, which subsequently impact metabolic factors. In some individuals, e. g., the very select group of healthy centenarians, the remodeling process is successful. The reasons why centenarians are able to reach the extreme limits of human life span are still largely unknown; however, several studies in humans have shown that longevity is associated with a significant improvement in glucose handling-mainly, a rise in insulin sensitivity and a decline in plasma insulin-like growth factor I levels. Conclusions: Caloric restriction seems to be the best positive modulator of metabolism to achieve longevity. Other specific metabolic adaptations, even those genetically induced, might also play a role in the health of centenarians. Copyright (C) 2009 S. Karger AG, Basel