Quantitative Susceptibility Mapping for Characterization of Intraplaque Hemorrhage and Calcification in Carotid Atherosclerotic Disease
Quantitative Susceptibility Mapping for Characterization of Intraplaque Hemorrhage and Calcification in Carotid Atherosclerotic Disease
复制标题
颈动脉粥样硬化性疾病斑块内出血和钙化特征的定量磁敏图。
DOI：
10.1002/jmri.27064
复制
发表时间：
2020-02-10
影响因子：
4.4
通讯作者：
Yang, Qi
中科院分区：
文献类型：
--
作者：
Wang, Chaoyue;Zhang, Yue;Yang, Qi
背景颈动脉斑块出血(IPH)是动脉粥样硬化的不稳定成分，与卒中风险增加有关。目的探讨定量磁化率图(QSM)作为评估IPH和活体钙化的工具。研究类型展望：10名健康志愿者和15名患者。磁场强度/序列3.0T磁化率加权成像(SWI)，磁化准备梯度回波快速采集(MP-RAGE)，T-1加权采样应用不同翻转角度进化的优化对比(T-1空间)，T-2加权快速自旋回波(T2W I)，用QSM测量颈动脉的管壁面积，并与T-1间隔进行比较。4名放射科医生对临床病史和患者身份视而不见，在MP-RAGE和QSM上确定了IPH的存在和面积，在T-1空间和QSM上确定了钙化面积。统计检验采用Bland-Altman分析、Pearson相关系数和线性回归分析来评估面积测量的一致性。分析Cohen‘s kappa(Kappa)以确定IPH检测之间的一致性。结果在423个匹配切片中，MP-RAGE和QSM的IPH发生率分别为20.1%(85/423)和19.6%(83/423)。QSM法和MP-RAGE法检测IPH有较好的一致性(kappa=0.822，P<；0.001)。QSM组和MP-RAGE组IPH面积测量结果差异无统计学意义(7.28 mm(2)+/-6.41vs.7.16mm(2)+/-5.99，P=0.575)。钙化面积测量值分别为3.51mm(2)+/-1.78vs.3.41mm(2)+/-2.02，P=0.783。结论QSM是一种新的诊断颈动脉粥样硬化性特发性高血压的影像工具，可区分特发性高血压和钙化。
Background Carotid artery intraplaque hemorrhage (IPH), an unstable component of atherosclerosis, is associated with an increased risk of stroke.Purpose To investigate quantitative susceptibility mapping (QSM) as a tool for the evaluation of IPH and calcification in vivo.Study Type Prospective.Population Ten healthy volunteers and 15 patients.Field Strength/Sequence 3.0T Susceptibility-weighted imaging (SWI), magnetization-prepared rapid acquisition with gradient echo (MP-RAGE), T-1-weighted sampling perfection with application of optimized contrasts using different flip angle evolution (T-1-SPACE), T-2-weighted turbo spin-echo (T2WI), and time-of-flight (TOF) sequences.Assessment The vessel wall area of the carotid artery was measured with QSM and compared with T-1-SPACE on healthy volunteers. Four radiologists, blinded to clinical history and patient identity, determined the presence and area of IPH on MP-RAGE and QSM, as well as the area of calcification on T-1-SPACE and QSM.Statistical Tests Bland-Altman analysis, Pearson correlation coefficients, linear regression analyses were performed to evaluate the concordance of area measurements. Cohen's kappa (kappa) was analyzed to determine the agreement between IPH detections. The paired t-test was used to compare the group differences.Results In 423 matched slices, 20.1% (85/423) and 19.6% (83/423) were detected to have IPH on MP-RAGE and QSM, respectively. IPH detection by QSM and MP-RAGE showed good agreement (kappa = 0.822, P < 0.001) between the two methods. There was no significant difference in IPH area measurements between QSM and MP-RAGE (7.28 mm(2) +/- 6.41 vs. 7.16 mm(2) +/- 5.99, P = 0.575). There was no significant difference in calcification area measurement between QSM and T-1-SPACE (3.51 mm(2) +/- 1.78 vs. 3.41 mm(2) +/- 2.02, P = 0.783).Data Conclusion QSM is a novel imaging tool for the identification of IPH in patients with carotid atherosclerosis and enables differentiation of IPH and calcification.Evidence Level 1Technical Efficacy Stage 1