Stimulation of arachidonic acid release and prostaglandin synthesis by bryostatin 1.
Stimulation of arachidonic acid release and prostaglandin synthesis by bryostatin 1.
复制标题
苔藓抑素 1 刺激花生四烯酸释放和前列腺素合成。
DOI：
10.1093/carcin/9.8.1471
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发表时间：
1988
期刊：
影响因子：
4.7
通讯作者：
Daniel,LW
中科院分区：
文献类型：
--
作者：
Parker,J;Waite,M;Pettit,GR;Daniel,LW
The mechanism of tumor promotion may involve stimulation of prostagladin production. Previous studies with the tumor promotor 12-O-tetradecanoylphorbol-13-acetate (TPA) have identified two effects of TPA on prostaglandin production. TPA stimulates both arachidonic acid release andde novosynthesis of prostaglandin H synthase. Activation of protein kinase C by TPA appears to be part of the mechanism to cause archidonic acid release. However, it is unclear if induction of prostaglandin H synthase also involves activation of protein kinase C. Bryostatin 1 is known to activate protein kinase C and to mimic some of the effects of TPA. We compared bryostatin 1 with TPA for the ability to cause arhidonic acid release and induced synthesis of prostaglandin H synthase. Bryostatin 1 induced arachidonic acid release and caused some prostaglandin production but only marginally induced synthesis of prostaglandin H synthase. Furthermore, we found that bryostatin 1 could inhibit the effect of TPA both in stimulation of arachidonic acid release and in the induction of prostaglandin H synthase.
