Comparative studies of susceptibility to infection in the Chediak-Higashi syndrome.
Comparative studies of susceptibility to infection in the Chediak-Higashi syndrome.
复制标题
Chediak-Higashi 综合征感染易感性的比较研究。
DOI：
10.1002/path.1700950224
复制
发表时间：
1968
期刊：
影响因子：
--
通讯作者：
J. Gorham
中科院分区：
文献类型：
--
作者：
G. Padgett;C. W. Reiquam;J. B. Henson;J. Gorham
患有Chediak-Higashi综合征（C-HS）的人、牛和水貂比非C-HS的人更容易感染传染病。据报道，所有受影响的儿童都更容易受到上呼吸道和其他细菌感染。在一年中，13头C-HS牛有46种不同的由各种微生物引起的感染，而18头非C-HS牛只有4种不同的感染。在同一时期，6头C-HS小牛死亡，但没有非C-HS小牛死亡。流行病学研究表明，与非C-HS水貂相比，C-HS水貂中阿留申病、棒状杆菌和冠状病毒感染的患病率和死亡率更高。实验感染阿留申病的Chediak-Higashi水貂平均死亡时间为102 d，非c - hs水貂平均死亡时间为241 d。[参见V.B. 38, abst。]1985.
Human beings, cattle and mink with the Chediak-Higashi syndrome (C-HS) are more susceptible to infectious diseases than non-C-HS individuals of the three species. All affected children have been reported to be more susceptible to upper respiratory and other bacterial infections. During a single year, 13 C-HS cattle had 46 distinct infections caused by various micro-organisms, whereas 18 non-C-HS cattle had only four separate infections. During the same period six C-HS calves died, but none of the non-C-HS calves. Epidemiological studies revealed that Aleutian disease and corynebacterium and pas-teurella infections had a higher prevalence and produced a higher mortality rate in C-HS than in non-C-HS mink., Chediak-Higashi mink experimentally infected with Aleutian disease had a mean death-time of 102 days, whereas the mean death-time of non-C-HS mink was 241 days. [See also V.B. 38, abst. 1985.