Structural brain abnormalities in patients with schizophrenia and their healthy siblings
Structural brain abnormalities in patients with schizophrenia and their healthy siblings
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DOI：
10.1176/appi.ajp.157.3.416
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发表时间：
2000-03-01
影响因子：
17.7
通讯作者：
Kahn, RS
中科院分区：
文献类型：
--
作者：
Staal, WG;Pol, HEH;Kahn, RS
目的：探讨基因型在精神分裂症患者脑结构异常中的作用。方法：采用磁共振成像技术测量32例精神分裂症不和谐同性兄弟姐妹和32例匹配对照者的大脑、白质和灰质、侧脑室和第三脑室、额叶、尾状核、杏仁核、海马、海旁回和小脑的颅内体积和体积。结果：精神分裂症患者与健康同胞的第三脑室容积无差异。然而，他们的第三脑室容积都比对照组高。精神分裂症患者的大脑体积低于对照组，而健康兄弟姐妹的大脑体积与患者或对照组没有显著差异。此外，与健康的兄弟姐妹和对照组相比，精神分裂症患者的额叶灰质体积减少，尾状核和侧脑室体积增加。颅内容积、脑脊液容积或小脑、杏仁核、海马或海马旁回的容积在患者、兄弟姐妹和对照组之间没有显著差异。结论：健康的兄弟姐妹与其患病亲属共享第三脑室增大，可能部分表现为脑容量减少。这些发现表明，第三脑室增大，以及在某种程度上脑容量减少，可能与导致精神分裂症易感性的遗传缺陷有关。
Objective: The authors sought to investigate the contribution of genotype on structural brain abnormalities in schizophrenia. Method: Intracranial volumes and volumes of the cerebrum, white and gray matter, lateral and third ventricles, frontal lobes, caudate nucleus, amygdala, hippocampus, parahippocampal gyrus, and the cerebellum were measured in 32 same-sex siblings discordant for schizophrenia and 32 matched comparison subjects by means of magnetic resonance imaging. Results: Third ventricle volumes did not differ between the schizophrenic patients and their healthy siblings. However, both had higher third ventricle volumes than did the comparison subjects. The schizophrenic patients had lower cerebrum volumes than did the comparison subjects, whereas the cerebrum volume of the healthy siblings did not significantly differ from the patients or comparison subjects. Additionally, patients with schizophrenia displayed a volume reduction of the frontal lobe gray matter and a volume increase of the caudate nuclei and lateral ventricles compared to both their healthy siblings and comparison subjects. Intracranial volume, CSF volume, or volumes of the cerebellum, amygdala, hippocampus, or the parahippocampal gyrus did not significantly differ among the patients, siblings, and comparison subjects. Conclusions: Healthy siblings share third ventricle enlargement with their affected relatives and may partially display a reduction in cerebral volume. These findings suggest that third ventricular enlargement, and to some extent cerebral volume decrease, may be related to genetic defects that produce a susceptibility to schizophrenia.