Polyglycerol mediated covalent construction of magnetic mesoporous silica nanohybrid with aqueous dispersibility for drug delivery
Polyglycerol mediated covalent construction of magnetic mesoporous silica nanohybrid with aqueous dispersibility for drug delivery
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聚甘油介导的具有水分散性的磁性介孔二氧化硅纳米杂化物的共价结构用于药物递送
DOI：
10.1016/j.msec.2017.06.022
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Zhao Li
中科院分区：
文献类型：
--
作者：
Yang Xiaoxin;Wen Yu;Wu Anqing;Xu Meiyun;Amano Tsukuru;Zheng Luyi;Zhao Li
构建具有化学稳定性和胶体稳定性的纳米杂化物对于探索其在生物医学领域的潜在应用具有重要意义。在这项工作中，开发了一种基于聚甘油（PG）介导的共价键的通用策略来制造核-卫星纳米杂化物，称为MMSN，其由作为核的介孔二氧化硅纳米颗粒（MSN）和在外表面上的许多超顺磁性氧化铁纳米颗粒（SPION）组成。在该合成策略中，PG接枝SPION被衍生化以将部分外围羟基转化为羧基部分，然后通过酰胺键连接到胺化MSN。PG层占MMSN的~ 17重量%，不仅作为连接两个纳米颗粒的系链，而且大大提高了纳米杂化物的胶体稳定性，导致流体动力学直径和ζ电位在四个月内没有显著变化。利用纳米杂化材料的多孔性和磁性，光敏剂二氢卟酚e6（Ce 6）被负载在MMSN上，并在磁性引导下有效地递送到靶细胞中，从而增强光动力治疗（PDT）的功效。这里提出的多功能策略开辟了一条新的路线，合理的设计和制造的多功能纳米杂化材料用于各种生物医学目的。
Construction of nanohybrids with chemical and colloidal stability is of great importance for the exploration of their potential applications in biomedical field. In this work, a versatile strategy based on polyglycerol (PG) mediated covalent linkage is developed to fabricate a core-satellite nanohybrid, termed MMSN, consisting of a mesoporous silica nanoparticle (MSN) as a core and many superparamagnetic iron oxide nanoparticles (SPION) on the outer surface. In this synthetic strategy, the PG grafted SPION is derivatized to convert partial periphery hydroxyl groups to carboxyl moieties, followed by attachment to aminated MSN through amide bonds. The PG layer accounting for ~ 17 wt% of MMSN not only serves as a tether to connect the two nanoparticles but also greatly enhances the colloidal stability of the nanohybrid, resulting in no significant change in hydrodynamic diameter and zeta potential during four months. Taking advantage of the combined porosity and magnetic property of the nanohybrid, a photosensitizer chlorin e6 (Ce6) is loaded on MMSN and efficiently delivered into target cells under magnetic guidance, leading to an enhanced efficacy of photodynamic therapy (PDT). The versatile strategy presented here opens up a new route to rational design and fabrication of multifunctional nanohybrids for various biomedical purposes.