Androgen-secreting adrenal tumors
Androgen-secreting adrenal tumors
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DOI：
10.1016/s0039-6060(03)00410-0
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发表时间：
2003-12-01
期刊：
影响因子：
3.8
通讯作者：
Young, W
中科院分区：
文献类型：
--
作者：
Cordera, F;Grant, C;Young, W
背景。专门分泌雄激素的肾上腺肿瘤极为罕见。本研究的目的是确定纯雄激素分泌性肾上腺肿瘤患者的特征。方法。 1946 年 1 月至 2002 年 11 月的回顾性图表审查确定了患有纯雄激素分泌性肾上腺肿瘤的女性患者。结果。平均年龄为 23.4 岁（范围：1-52）。最常见的症状是多毛症、痤疮和阴蒂增大。 9 名接受测试的患者中有 7 名发现 17-酮类固醇水平升高。七名患者中的六名进行了计算机断层扫描、超声检查或两者都进行了局部肿瘤检查。所有肿瘤均通过手术切除，其中一例通过腹腔镜切除，均无并发症。其中五个肿瘤是恶性的。良性和恶性肿瘤的平均重量和平均最大直径分别为44克和4.2厘米以及232克和9.8厘米。平均住院时间为 8.5 天，所有患者雄激素分泌过多的问题得到解决。只有一名诊断时患有肺转移的患者出现复发和疾病相关死亡。其余患者在平均随访 11.7 年（范围：0.5-32 年）时没有肿瘤复发。结论。纯粹产生雄激素的肿瘤极为罕见。大约 50% 是良性的，如果诊断时肿瘤没有转移，手术切除可以提供良好的治疗。
Background. Adrenal tumors that secrete androgens exclusively are extraordinarily rare. The aim of this study was to characterize patients with pure androgen-secreting adrenal tumors.Methods. A retrospective chart review from January 1946 through November 2002 identified I I female patients with pure androgen-secreting adrenal tumors.Results. The mean age was 23.4 years (range, 1-52). The most common presenting symptoms were hirsutism, acne, and clitoral enlargement. Elevated 17-ketosteroids were found in seven of nine tested patients. Computed tomogram, ultrasound, or both localized tumors in six of seven patients. All tumors were surgically resected, one laparoscopically, all without complications. Five of the I I tumors were malignant. Mean weight and mean maximal diameter for benign and malignant tumors were 44 g and 4.2 cm and 232 g and 9.8 cm, respectively. Mean hospital stay was 8.5 days, with excess androgen production resolved in all patients. Recurrence and disease-related death occurred in only one patient who had pulmonary metastases at diagnosis. The remaining patients had no recurrence of tumor at mean follow-up of 11.7 years (range, 0.5-32 years).Conclusions. Pure androgen-producing tumors are extremely rare. Approximately 50% are benign, and surgical resection provides excellent treatment if the tumors are not metastatic at the time of diagnosis.