C1q and its growing family
C1q and its growing family
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DOI：
10.1016/j.imbio.2006.11.001
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发表时间：
2007-01-01
期刊：
影响因子：
2.8
通讯作者：
Kishore, Uday
中科院分区：
文献类型：
--
作者：
Ghai, Rohit;Waters, Patrick;Kishore, Uday
Clq是经典补体途径的靶识别蛋白，并且是先天性和获得性免疫之间的主要连接纽带。作为先天免疫的电荷模式识别分子，Clq可以通过其异源三聚体球状（gClq）结构域与广泛的自身和非自身配体结合，从而触发经典途径。三聚体gClq特征结构域已经在多种非补体蛋白中被鉴定，其可以一起被分组为Clq家族。一些Clq家族成员的gClq结构域的X射线晶体结构揭示了与多功能肿瘤坏死因子（TNF）配体家族类似的紧凑的卷曲P-夹心折叠，因此是Clq和TNF超家族。本文综述了人Clq的gClq结构域的结构和功能方面的最新进展。我们还提到了利用gClq结构域的各种蛋白质，以反映其作为支持各种功能的通用支架的重要性。(c)2006年Elsevier GmbH。All rights reserved.
Clq is the target recognition protein of the classical complement pathway and a major connecting link between innate and acquired immunity. As a charge pattern recognition molecule of innate immunity, Clq can engage a broad range of self and non-self ligands via its heterotrimeric globular (gClq) domain and thus trigger the classical pathway. The trimeric gClq signature domain has been identified in a variety of non-complement proteins that can be grouped together as a Clq family. The X-ray crystal structures of the gClq domain of a few members of the Clq family reveal a compact jelly-roll P-sandwich fold similar to that of the multifunctional tumor necrosis factor (TNF) ligand family, hence the Clq and TNF superfamily. This review is an update on the structural and functional aspects of the gClq domain of human Clq. We also mention the diverse range of proteins that utilize a gClq domain in order to reflect on its importance as a versatile scaffold to support a variety of functions. (c) 2006 Elsevier GmbH. All rights reserved.