Relationship Between Spontaneous Passage Rates of Ureteral Stones Less Than 8 mm and Serum C-Reactive Protein Levels and Neutrophil Percentages.
Relationship Between Spontaneous Passage Rates of Ureteral Stones Less Than 8 mm and Serum C-Reactive Protein Levels and Neutrophil Percentages.
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DOI：
10.4111/kju.2013.54.9.615
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发表时间：
2013-09
期刊：
影响因子：
--
通讯作者：
Kim BH
中科院分区：
文献类型：
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作者：
Park CH;Ha JY;Park CH;Kim CI;Kim KS;Kim BH
由输尿管结石引起的输尿管梗阻会导致近端粘膜下层的炎性改变，并阻止输尿管结石的自发通过。因此，我们分析了直径小于8 mm的输尿管结石的自然通畅率与血清C-反应蛋白(CRP)水平和中性粒细胞百分比的关系。对2001年1月至2011年1月在Keimyung大学东山医学中心连续治疗的187例输尿管结石患者进行回顾性分析。输尿管结石取石定义为在诊断后8周内，在影像检查中未发现输尿管结石而未经任何治疗。根据血清C反应蛋白水平将患者分为三组，并根据中性粒细胞百分比将患者分为两组。然后检查这些因素与输尿管结石通过率之间的关系。低、中、高三组输尿管结石通石率分别为94.1%(159/169)、70%(7/10)、50.0%(4/8)。中性粒细胞比例正常组和中性粒细胞比例较高组输尿管结石通畅率分别为94.5%和83.1%(P=0.011)。对输尿管结石直径小于8 mm的患者进行血清CRP水平和中性粒细胞百分比的检测，有助于预测结石是否自然排出。当患者的血清CRP水平和中性粒细胞百分比较高时，应考虑积极的治疗，如体外冲击波碎石术。
A ureter obstruction caused by a ureteral stone results in inflammatory changes in the proximal submucosal layer and prevents the spontaneous passage of the ureteral stone. Accordingly, we analyzed the relationship between the spontaneous passage rates of ureteral stones less than 8 mm in size and serum C-reactive protein (CRP) levels and neutrophil percentages. A total of 187 patients who were diagnosed with ureteral stones less than 8 mm in size and were managed consecutively at Keimyung University Dongsan Medical Center from January 2001 to January 2011 were retrospectively analyzed. Ureteral stone removal was defined as no ureteral stone shown in an imaging test without any treatment for 8 weeks after diagnosis. The patients were divided into three groups according to the levels of serum CRP and into two groups according to neutrophil percentage. The associations between these factors and ureteral stone passage rates were then examined. The ureteral stone passage rates of the low serum CRP level group, the medium serum CRP level group, and the high serum CRP level group were 94.1% (159/169), 70% (7/10), and 50.0% (4/8), respectively. The passage rates of ureteral stones in the group with a normal neutrophil percentage and in the group with a higher neutrophil percentage were 94.5% (121/128) and 83.1% (49/59), respectively (p=0.011). Measuring serum CRP levels and neutrophil percentages in patients with small ureteral stones of less than 8 mm is useful in predicting whether the stone will be spontaneously passed. When the serum CRP level and neutrophil percentage of a patient are high, aggressive treatment such as extracorporeal shock wave lithotripsy should be considered.