Increased white matter connectivity in euthymic bipolar patients: diffusion tensor tractography between the subgenual cingulate and the amygdalo-hippocampal complex
Increased white matter connectivity in euthymic bipolar patients: diffusion tensor tractography between the subgenual cingulate and the amygdalo-hippocampal complex
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DOI：
10.1038/sj.mp.4002010
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发表时间：
2007-11-01
影响因子：
11
通讯作者：
Paillere-Martinot, M-L
中科院分区：
文献类型：
--
作者：
Houenou, J.;Wessa, M.;Paillere-Martinot, M-L
双相情感障碍与大脑网络中的解剖学和功能异常有关，该网络介导正常和受损的情绪调节。先前的脑成像研究强调了扣带回（SC）和杏仁-海马（AH）复合体作为该网络的核心区域。因此，我们调查了白色纤维束之间的SC和AH区，钩束，以及两个控制区（脑桥和小脑），使用扩散张量成像纤维束成像在16个正常的胸腺双相患者（BP）和16个性别，年龄和利手匹配的对照。比较各组重建纤维束的各向异性分数（FA）、表观扩散系数（ADC）及虚拟重建纤维的数目。纤维束成像结果显示，与健康对照组相比，BP患者左侧SC和左侧AH之间的重建纤维数量显著增加。重建纤维束的FA和ADC在组间无显著差异。此外，无论是右SC和右AH之间的重建纤维束，还是对照区域之间，均未观察到显著的组间差异。目前的结果表明，改变WM通路之间的左SC和AH区域，从而扩展了以前的研究结果，在BP这些结构的解剖和功能的修改。
Bipolar disorder has been associated with anatomical as well as functional abnormalities in a brain network that mediates normal and impaired emotion regulation. Previous brain imaging studies have highlighted the subgenual cingulate (SC) and the amygdalo-hippocampal (AH) complex as core regions of this network. Thus we investigated white matter (WM) fiber tracts between the SC and the AH region, the uncinate fasciculus, as well as between two control regions (pons and cerebellum), using diffusion tensor imaging tractography in 16 euthymic bipolar patients (BP) and 16 sex-, age-and handedness-matched controls. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) of the reconstructed fiber bundle and the number of virtual reconstructed fibers were compared between groups. The tractography results revealed a significantly increased number of reconstructed fibers between the left SC and left AH in BP as compared to healthy controls. FA and ADC of the reconstructed fiber tract did not differ significantly between the groups. Furthermore, no significant group differences were observed neither for reconstructed fiber tracts between the right SC and right AH nor between the control regions. The present results suggest an altered WM pathway between the left SC and AH region and thus extend previous findings of anatomical and functional modifications in these structures in BP.