Association of dopamine D4 receptor (DRD4) exon III repeat polymorphism with temperament in 3-year-old infants
Association of dopamine D4 receptor (DRD4) exon III repeat polymorphism with temperament in 3-year-old infants
复制标题
多巴胺 D4 受体（DRD4）外显子 III 重复多态性与 3 岁婴儿性情的关系
DOI：
10.1007/s10048-003-0146-z
复制
发表时间：
2003-08-01
期刊：
影响因子：
2.2
通讯作者：
Dallapiccola, B
中科院分区：
文献类型：
--
作者：
De Luca, A;Rizzardi, M;Dallapiccola, B
多巴胺D4受体（DRD 4）外显子III重复多态性（L-DRD 4）的长型在一些研究中与成人的新奇寻求（NS）人格特质以及与兴趣和活动相关的婴儿人格特质有关。目前的调查扩展了我们以前的纵向研究的结果，对1至5个月大的新生儿评估的早期和修订的婴儿气质问卷（EITQ/RITQ），其中我们发现了一个显着的相关性DRD 4多态性和适应性性状在1个月大。在这项研究中，我们研究了儿童在3岁的行为，测量与幼儿气质量表（TTS），和DRD 4外显子III重复多态性之间的关系。我们发现反应强度的行为维度与DRD 4基因型之间存在显著关联。目前的数据未能证实与适应性特质的关联。正如预期的那样，外向性和/或探索性行为指标均与L-DRD 4等位基因无关。相反，与4/4基因型相比，4/7基因型的儿童对新刺激的反应更差。这项研究只是部分证实了先前关于DRD 4基因与人类气质之间联系的结果。
The long forms of the dopamine D4 receptor (DRD4) exon III repeat polymorphism (L-DRD4) have been linked in some studies to the adult personality trait of novelty seeking (NS), as well as to infant personality traits related to interest and activity. The current investigation extends the results of our previous longitudinal study on 1- to 5-month-old neonates assessed by the Early and Revised Infancy Temperament Questionnaire (EITQ/RITQ), in which we found a significant correlation between the DRD4 polymorphism and the adaptability trait at 1 month of age. In this study, we examined the relationship between children's behavior at 3 years of age, measured with the Toddler Temperament Scale (TTS), and DRD4 exon III repeat polymorphism. We found a significant association between the behavioral dimension of intensity of reaction and DRD4 genotypes. Current data failed to confirm the association with the adaptability trait. None of the extraversion and/or exploratory behavior measures was related to the L-DRD4 allele, as expected. In contrast, children with 4/7 genotypes showed worse response to new stimuli compared with 4/4 genotypes. This study corroborates only in part previous results on the link between the DRD4 gene and human temperament.