Oral candidiasis: pathogenesis and host defense.
Oral candidiasis: pathogenesis and host defense.
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口腔念珠菌病：发病机制和宿主防御。
DOI：
10.1093/clinids/6.1.96
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Izutzu,KT
中科院分区：
文献类型：
--
作者：
Epstein,JB;Truelove,EL;Izutzu,KT
口腔念珠菌病是一个常见的问题，经常表现为慢性反复感染。口腔感染是宿主体内严重、传播、局部疾病和全身性疾病的潜在宿主。宿主防御中的非特异性局部口腔因子包括上皮屏障、唾液流动、微生物相互作用、唾液的抗菌成分、溶菌酶、乳铁蛋白、乳过氧化物酶系统、铁水平和唾液糖蛋白。免疫球蛋白存在于唾液中，但人们对其作用知之甚少。口腔粘膜表面抗念珠菌抗体的活性可能不受补体和吞噬细胞活性的介导。针对念珠菌的特异性抗体可能通过聚集生物体和防止真菌的肌肉粘附而起作用。
Oral candidiasis is a common problem, frequently presenting as a chronic recurring infection. Oral infection is a potential reservoir of organisms for severe, spreading, local disease and systemic disease in the compromised host. Nonspecific local oral factors in host defense include the epithelial barrier, flow of saliva, microbial interactions, antimicrobial constituents of saliva, lysozyme, lactoferrin, the lactoperoxidase system, levels of iron, and salivary glycoproteins. Immunoglobins are present in saliva, but their role is poorly understood. The activity of antibody againstCandidaon oral mucosal surfaces may not be mediated by complement and phagocyte activity. Specific antibodies againstCandidamay function by aggregating the organisms and preventing musocal adherence of the fungi.