Ca(2+)-dependent sugar recognition by animal lectins.
Ca(2+)-dependent sugar recognition by animal lectins.
复制标题
动物凝集素对 Ca(2) 依赖性糖的识别。
DOI：
10.1042/bst0240146
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发表时间：
1996
影响因子：
3.9
通讯作者：
Drickamer,K
中科院分区：
文献类型：
--
作者：
Drickamer,K
附着在动物细胞表面和细胞外蛋白质上的碳水化合物的许多生物学功能是通过内源性动物凝集素的识别来调节的[11.一组特别大和多样化的内源性糖结合蛋白，即C型动物凝集素，含有依赖于钙的碳水化合物识别结构域(CRD)[2]。在过去的5年里，我们对碳水化合物识别过程的理解已经转移到分子和原子水平。X射线结晶学和定点突变相结合，揭示了单个CRD如何对不同组的单糖实现选择性，以及完整的动物凝集素如何区分不同的寡糖。
Many of the biological functions of carbohydrates attached to animal cell surfaces and extracellular proteins are mediated through recognition by endogenous animal lectins [11. One particularly large and diverse set of endogenous sugar-binding proteins, the C-type animal lectins, contain Ca2'-dependent carbohydrate-recognition domains (CRDs)[2]. Over the past 5 years, our understanding of carbohydrate recognition processes has moved to the molecular and atomic levels. A combination of X-ray crystallography and site-directed mutagenesis has revealed how individual CRDs achieve selectivity for distinct sets of monosaccharides and how intact animal lectins discriminate between various oligosaccharides.