PRAME expression in head and neck cancer correlates with markers of poor prognosis and might help in selecting candidates for retinoid chemoprevention in pre-malignant lesions.
PRAME expression in head and neck cancer correlates with markers of poor prognosis and might help in selecting candidates for retinoid chemoprevention in pre-malignant lesions.
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DOI：
10.1016/j.oraloncology.2012.08.005
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发表时间：
2013-02
期刊：
影响因子：
4.8
通讯作者：
Whiteside, Theresa L.
中科院分区：
文献类型：
--
作者：
Szczepanski, Miroslaw J.;DeLeo, Albert B.;Luczak, Michal;Molinska-Glura, Marta;Misiak, Jan;Szarzynska, Bronislawa;Dworacki, Grzegorz;Zagor, Mariola;Rozwadowska, Natalia;Kurpisz, Maciej;Krzeski, Antoni;Kruk-Zagajewska, Aleksandra;Kopec, Tomasz;Banaszewski, Jacek;Whiteside, Theresa L.
关键词：
PRAME (Preferentially Expressed Antigen in Melanoma) is a tumor-associated antigen recognized by immunocytes, and it induces cytotoxic T cell-mediated responses in melanoma. PRAME expression in tumors interferes with retinoic acid receptor (RAR) signaling thus promoting tumor progression. Here, we study PRAME expression in head and neck squamous cell carcinoma (HNSCC) to determine its potential clinical significance. PRAME expression in HNSCC was evaluated by immunohistochemistry in tissue microarrays of primary tumors (n=53), metastatic lymph nodes (n=8) and normal oral mucosa (n=11). Biopsies of dysplastic oral lesions (n=12) were also examined. PRAME expression levels in tissues were correlated with markers of poor prognosis in HNSCC. PRAME mRNA in HNSCC cell lines and in normal immortalized human keratinocytes (HaCaT cell line) was measured by qRT-PCR, and the protein expression by flow cytometry and western blots. PRAME was expressed in HNSCC cell lines and HNSCC lesions. PRAME expression in dysplastic mucosa was variable. No or only weak expression was found in normal cells or tissues. PRAME expression levels significantly correlated with the tumor grade, size, nodal involvement and the clinical status of HNSCC patients. Elevated PRAME expression associates with clinicopathologic markers of poor outcome in HNSCC and might identify potential candidates with pre-cancerous lesions for chemoprevention with retinoids.
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影响因子：
11.5
作者：
Meissner, M;Reichert, TE;Seliger, B
通讯作者：
Seliger, B
影响因子：
12.8
作者：
Atanackovic, Djordje;Luetkens, Tim;Kroeger, Nicolaus
通讯作者：
Kroeger, Nicolaus
影响因子：
6.4
作者：
Cuffel, Cyril;Rivals, Jean-Paul;Rimoldi, Donata
通讯作者：
Rimoldi, Donata
DOI：
10.1621/nrs.07006
发表时间：
2009-05-12
期刊：
Nuclear receptor signaling
影响因子：
--
作者：
Dollé P
通讯作者：
Dollé P
影响因子：
45.3
作者：
Cullen, Kevin J.;Schumaker, Lisa;Posner, Marshall R.
通讯作者：
Posner, Marshall R.