The Schizophrenia Patient Outcomes Research Team (PORT): Updated Treatment Recommendations 2009
The Schizophrenia Patient Outcomes Research Team (PORT): Updated Treatment Recommendations 2009
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DOI：
10.1093/schbul/sbp130
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发表时间：
2010-01-01
影响因子：
6.6
通讯作者：
Dixon, Lisa B.
中科院分区：
文献类型：
--
作者：
Kreyenbuhl, Julie;Buchanan, Robert W.;Dixon, Lisa B.
精神分裂症患者结局研究小组（PORT）项目在精神分裂症循证实践的发展和传播方面发挥了重要作用。与其他临床指南相比，最初于1998年出版并于2003年首次修订的精神分裂症PORT治疗建议主要基于经验数据。在过去5年中，精神分裂症的精神药理学和社会心理治疗研究不断发展，有必要更新PORT建议。在与专家顾问协商后，2个证据审查小组（ERGs）确定了41个治疗领域进行审查，并进行了电子文献检索，以确定自上次PORT文献审查以来发表的所有临床研究。研究小组还审查了2002年以前在以前的PORT审查未涵盖的领域的研究，包括戒烟、药物滥用和减肥。专家小组审查了600多项研究，并综合了研究证据，提出了证据充分、值得推荐的治疗方法的建议。对于那些缺乏经验支持的治疗方法，研究小组提出了平行的总结声明。一个由39名精神分裂症研究人员、临床医生和消费者组成的专家小组参加了2008年11月的一次会议，会上就所审查的每个治疗领域的证据状况达成了共识。本文介绍了更新过程的方法和结果，并对精神分裂症的16种精神药理学治疗和8种社会心理治疗提出了建议。另有13种精神药理学治疗和4种社会心理治疗没有足够的证据来支持建议，这表明在重要的治疗领域有明显的未满足需求。
The Schizophrenia Patient Outcomes Research Team (PORT) project has played a significant role in the development and dissemination of evidence-based practices for schizophrenia. In contrast to other clinical guidelines, the Schizophrenia PORT Treatment Recommendations, initially published in 1998 and first revised in 2003, are based primarily on empirical data. Over the last 5 years, research on psychopharmacologic and psychosocial treatments for schizophrenia has continued to evolve, warranting an update of the PORT recommendations. In consultation with expert advisors, 2 Evidence Review Groups (ERGs) identified 41 treatment areas for review and conducted electronic literature searches to identify all clinical studies published since the last PORT literature review. The ERGs also reviewed studies preceding 2002 in areas not covered by previous PORT reviews, including smoking cessation, substance abuse, and weight loss. The ERGs reviewed over 600 studies and synthesized the research evidence, producing recommendations for those treatments for which the evidence was sufficiently strong to merit recommendation status. For those treatments lacking empirical support, the ERGs produced parallel summary statements. An Expert Panel consisting of 39 schizophrenia researchers, clinicians, and consumers attended a conference in November 2008 in which consensus was reached on the state of the evidence for each of the treatment areas reviewed. The methods and outcomes of the update process are presented here and resulted in recommendations for 16 psychopharmacologic and 8 psychosocial treatments for schizophrenia. Another 13 psychopharmacologic and 4 psychosocial treatments had insufficient evidence to support a recommendation, representing significant unmet needs in important treatment domains.