Ovarian cancer risk factors by tumor aggressiveness: An analysis from the Ovarian Cancer Cohort Consortium
Ovarian cancer risk factors by tumor aggressiveness: An analysis from the Ovarian Cancer Cohort Consortium
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DOI：
10.1002/ijc.32075
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发表时间：
2019-07-01
影响因子：
6.4
通讯作者：
Tworoger, Shelley S.
中科院分区：
文献类型：
--
作者：
Fortner, Renee T.;Poole, Elizabeth M.;Tworoger, Shelley S.
卵巢癌的危险因素因组织型而异；然而，在亚型中，结果有很大的可变性。我们假设危险因素可能影响肿瘤侵袭性，由诊断和死亡之间的时间定义，独立于组织学。在来自21个前瞻性队列的130万名妇女中，鉴定出4584例浸润性上皮性卵巢癌，并将其归类为高度侵袭性（死亡时间为10年）
Ovarian cancer risk factors differ by histotype; however, within subtype, there is substantial variability in outcomes. We hypothesized that risk factor profiles may influence tumor aggressiveness, defined by time between diagnosis and death, independent of histology. Among 1.3 million women from 21 prospective cohorts, 4,584 invasive epithelial ovarian cancers were identified and classified as highly aggressive (death in