Human fetuses do not register chromosome damage inflicted by radiation exposure in lymphoid precursor cells except for a small but significant effect at low doses
Human fetuses do not register chromosome damage inflicted by radiation exposure in lymphoid precursor cells except for a small but significant effect at low doses
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DOI：
10.1667/3147
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发表时间：
2004-04-01
影响因子：
3.4
通讯作者：
Nakamura, N
中科院分区：
文献类型：
--
作者：
Ohtaki, K;Kodama, Y;Nakamura, N
人类胎儿被认为对辐射高度敏感，因为诊断性低剂量 X 射线被认为会增加儿童患白血病的风险。然而，动物研究通常并未证明胎儿具有高放射敏感性，而且造成这种差异的根本原因仍未确定。我们检查了子宫内暴露的原子弹幸存者 40 岁时血液淋巴细胞的易位频率。与我们对胎儿放射敏感性高于成人的预期相反，除了小幅增加外，频率并未随剂量增加而增加（
Human fetuses are thought to be highly sensitive to radiation exposure because diagnostic low-dose X rays have been suggested to increase the risk of childhood leukemia. However, animal studies generally have not demonstrated a high radiosensitivity of fetuses, and the underlying causes for the discrepancy remain unidentified. We examined atomic bomb survivors exposed in utero for translocation frequencies in blood lymphocytes at 40 years of age. Contrary to our expectation of a greater radiosensitivity in fetuses than in adults, the frequency did not increase with dose except for a small increase (