Seeing is believing: the impact of RB on nuclear organization.
Seeing is believing: the impact of RB on nuclear organization.
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DOI：
10.1080/15384101.2023.2206352
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发表时间：
2023-06
期刊：
影响因子：
4.3
通讯作者：
Dyson, Nicholas J.
中科院分区：
文献类型：
--
作者：
Krishnan, Badri;Sanidas, Ioannis;Dyson, Nicholas J.
视网膜母细胞瘤肿瘤抑制因子（RB）通过抑制E2 F活性阻止G1至S细胞周期转变。这种功能需要RB保持未磷酸化或磷酸化不足（所谓的RB活性形式）。最近，我们发现RB的活性形式导致在显微镜下可见的核结构的广泛变化。这些表型与细胞周期停滞或E2 F转录程序的抑制无关，但出现较晚，并且与自噬的出现或具有衰老标记的IMR-90细胞相关。从这个角度来看，我们描述了这些RB诱导的事件的相对时间，并讨论了RB诱导的染色质分散的机制。我们认为RB诱导的分散，自噬和衰老之间的关系和分散和细胞周期退出之间的潜在联系。
The retinoblastoma tumor suppressor (RB) prevents G1 to S cell cycle transition by inhibiting E2F activity. This function requires that RB remains un- or underphosphorylated (the so-called active forms of RB). Recently, we showed that active forms of RB cause widespread changes in nuclear architecture that are visible under a microscope. These phenotypes did not correlate with cell cycle arrest or repression of the E2F transcriptional program, but appeared later, and were associated with the appearance of autophagy or in IMR-90 cells with senescence markers. In this perspective, we describe the relative timing of these RB-induced events and discuss the mechanisms that may underlie RB-induced chromatin dispersion. We consider the relationship between RB-induced dispersion, autophagy, and senescence and the potential connection between dispersion and cell cycle exit.
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