OXYGEN RADICALS IN INFLUENZA-INDUCED PATHOGENESIS AND TREATMENT WITH PYRAN POLYMER-CONJUGATED SOD
OXYGEN RADICALS IN INFLUENZA-INDUCED PATHOGENESIS AND TREATMENT WITH PYRAN POLYMER-CONJUGATED SOD
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DOI：
10.1126/science.2543070
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发表时间：
1989-05-26
期刊：
影响因子：
56.9
通讯作者：
MAEDA, H
中科院分区：
文献类型：
--
作者：
ODA, T;AKAIKE, T;MAEDA, H
流感病毒感染小鼠的致病性至少部分涉及宿主免疫反应的过度反应，而不是病毒增殖的直接影响。在流感病毒感染小鼠的血清和肺组织中，负责产生氧自由基的黄嘌呤氧化酶升高。为了验证氧自由基参与发病机制的理论，通过注射超氧化物歧化酶（SOD）来清除自由基，超氧化物歧化酶是一种特异性超氧化物自由基清除剂，其与吡喃共聚物缀合。如果在感染后5至8天给药，缀合物保护小鼠免受潜在致命的流感病毒感染。这些研究结果表明，氧自由基是重要的流感病毒感染的发病机制，和聚合物结合的SOD具有治疗潜力，这种病毒感染和其他疾病与自由基。
The pathogenicity of influenza virus infection in the mice involves, at least in part, overreaction of the immune responses of the host rather than a direct effect of virus multiplication. Xanthine oxidase, which is responsible for the generation of oxygen free radicals, was elevated in serum and lung tissue of mice infected with influenza virus. To test the theory that oxygen-free radicals are ivolved in pathogenesis, free radicals were removed by injecting superoxide dismutase (SOD), a specific superoxide radical scavenger, which was conjugated with a pyran copolymer. The conjugate protected mice against a potentially lethal influenza virus infection if administered 5 to 8 days after infection. These findings indicate that oxygen radicals are important in the pathogenesis of influenza virus infection, and that a polymer-conjugated SOD has therapeutic potential for this virus infection and other diseases associated with free radicals.