LEUKOCYTE COUNT CORRELATES IN MIDDLE-AGED ADULTS - THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY
LEUKOCYTE COUNT CORRELATES IN MIDDLE-AGED ADULTS - THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY
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DOI：
10.1093/oxfordjournals.aje.a116530
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发表时间：
1992-09-01
影响因子：
5
通讯作者：
MERCURI, M
中科院分区：
文献类型：
--
作者：
NIETO, FJ;SZKLO, M;MERCURI, M
1986年，在美国四个社区开展的社区动脉粥样硬化风险研究中，对14,679名年龄在45岁-之间的参与者进行了白细胞计数与社会人口学和心血管危险因素之间的横断面相关性调查。白细胞计数与现在或过去的吸烟史密切相关，男性高于女性，白人高于黑人。在从不吸烟的人中，调整了其他危险因素后，没有明显的性别差异。在多变量分析中考虑了其他因素后，与种族相关的差异大大减少。在从不吸烟的人中，报告健康状况不佳的人的白细胞计数更高，并且与高密度脂蛋白胆固醇、1秒用力呼气量、体力活动以及白人的身高和社会经济指标呈负相关。与体重、体脂、心率、血压、血红蛋白、血小板计数、尿酸、空腹胰岛素、血糖、甘油三酯、纤维蛋白原、抗凝血酶III、蛋白C、因子VII和VIII、von Willebrand因子直接相关。白细胞计数与心血管危险因素的相关性可能代表亚临床疾病的表现，或者提示白细胞计数是导致动脉粥样硬化的因果链的一部分。或者，白细胞计数与心血管疾病的关系可能会被危险因素混淆，因此是非因果的。
Cross-sectional associations between leukocyte count and sociodemographic and cardiovascular risk factors were investigated in 14,679 participants aged 45-64 years in the Atherosclerosis Risk in Communities Study carried out in four US communities in 1986-1989. Leukocyte count was strongly associated with present or past history of cigarette smoking and was higher in males than in females and in white subjects than in black subjects. Among never smokers, no sex differences were evident after adjustment for other risk factors. Race-associated differences were substantially reduced after other factors were taken into account in multivariate analyses. In never smokers, leukocyte count was higher in those who reported poor health, and it was inversely associated with high density lipoprotein cholesterol, forced expiratory volume at 1 second, physical activity, and, among whites, height and socioeconomic indicators. It was directly associated with indices of body weight and body fat, heart rate, blood pressure, hemoglobin, platelet count, uric acid, fasting insulin and glycemia, triglycerides, fibrinogen, antithrombin III, protein C, factors VII and VIII, and von Willebrand factor. The associations of leukocyte count with cardiovascular risk factors may either represent manifestation of subclinical disease or suggest that leukocyte count is part of the causal chain leading to atherosclerosis. Alternatively, the relation of leukocyte count to cardiovascular disease may be confounded by risk factors and thus be noncausal.