Effects of arundic acid, an astrocytic modulator, on the cerebral and respiratory functions in severe hypoxia
Effects of arundic acid, an astrocytic modulator, on the cerebral and respiratory functions in severe hypoxia
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DOI：
10.1016/j.resp.2015.11.011
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发表时间：
2016-06-01
影响因子：
2.3
通讯作者：
Okada, Yasumasa
中科院分区：
文献类型：
--
作者：
Fukushi, Isato;Takeda, Kotaro;Okada, Yasumasa
轻度缺氧可增加通气功能，而重度缺氧则可抑制通气功能，其机制，尤其是大脑的功能作用，目前尚不完全清楚。胶质细胞生理学的最新进展为星形胶质细胞在各种脑功能的信息处理中发挥积极作用提供了证据。我们研究了这一假设，即星形胶质细胞的激活是必要的，以维持脑功能和通气缺氧，通过检查脑电图和通气严重缺氧前和后管理的星形胶质细胞功能的调节剂，arundic酸，在未麻醉小鼠的反应。用全身体积描记法测定通气参数。当出现低氧性抑郁时，EEG的γ频段被抑制。Arundic acid进一步抑制通气，并且EEG功率以剂量依赖性方式被抑制。Arundic acid还抑制缺氧诱导的下丘脑c-Fos表达。我们的结论是，严重的缺氧抑制脑功能，这可能会减少刺激脑干导致解释性抑郁症。缺氧时星形胶质细胞的激活可抵消脑抑制和脑抑制。(C)2015年由Elsevier B. V.出版
Mild hypoxia increases ventilation, but severe hypoxia depresses it. The mechanism of hypoxic ventilatory depression, in particular, the functional role of the cerebrum, is not fully understood. Recent progress in glial physiology has provided evidence that astrocytes play active roles in information processing in various brain functions. We investigated the hypothesis that astrocytic activation is necessary to maintain the cerebral function and ventilation in hypoxia, by examining the responses of EEG and ventilation to severe hypoxia before and after administration of a modulator of astrocytic function, arundic acid, in unanesthetized mice. Ventilatory parameters were measured by whole body plethysmography. When hypoxic ventilatory depression occurred, gamma frequency band of EEG was suppressed. Arundic acid further suppressed ventilation, and the EEG power was suppressed in a dose-dependent manner. Arundic acid also suppressed hypoxia-induced c-Fos expression in the hypothalamus. We conclude that severe hypoxia suppresses the cerebral function which could reduce the stimulus to the brainstem resulting in ventilatory depression. Astrocytic activation in hypoxia may counteract both cerebral and ventilatory suppression. (C) 2015 Published by Elsevier B.V.