Evaluation of cartilage matrix disorders by T2 relaxation time in patients with hip dysplasia
Evaluation of cartilage matrix disorders by T2 relaxation time in patients with hip dysplasia
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DOI：
10.1016/j.joca.2007.06.003
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发表时间：
2008-02-01
影响因子：
7
通讯作者：
Yoshikawa, H.
中科院分区：
文献类型：
--
作者：
Nishii, T.;Tanaka, H.;Yoshikawa, H.
目的：早期发现髋关节发育不良患者的软骨紊乱，对于预测骨性关节炎的进展和确定合适的截骨手术时机具有重要意义。方法：对10例正常志愿者(14个髋关节)和23例(26个髋关节发育不良)患者关节前期(无骨关节炎)或早期(Kellgren-Lawrence系统1~2级骨关节炎)，用3T磁共振成像获得髋关节矢状位T2图。比较正常组、关节炎前期组和早期关节炎组髋臼和股软骨上端的T2值及T2梯度、低T2和高T2的视觉表现。结果：三组关节软骨的T2值差异无统计学意义。在髋臼软骨T2图的视觉表现上，正常组所有髋关节均呈梯度T2型，而关节炎前期组有6个髋关节(43%)呈低T2型，早期关节炎组表现为低T2型(33%)或高T2型(67%)。发育不良的髋关节、髋臼和股骨软骨的T2梯度模式频率明显低于正常髋关节(P<；0.05)。结论：初步研究证实了3T磁共振成像评价髋关节软骨T2的临床可行性。T2标测分型可早期发现髋关节发育不良患者的骨关节退行性变和软骨基质发育障碍。(C)2007年国际骨性关节炎研究会。爱思唯尔有限公司出版。保留所有权利。
Objective: Early detection of cartilage disorder in dysplastic hips is important in predicting subsequent progression of osteoarthritis and determining the appropriate timing of osteotomy surgery. We assessed the feasibility of T2 assessment using magnetic resonance (MR) imaging at 3 T for evaluating early changes in the acetabular and femoral cartilages for patients with hip dysplasia.Methods: Sagittal T2 maps of the hip were obtained using 3 T MR imaging in 10 normal volunteers (14 hips) and in 23 patients (26 hips) with hip dysplasia at pre-arthritic stage (without osteoarthritis) or early-arthritic stage (with osteoarthritis at the Kellgren-Lawrence system of grade 1 or 2). T2 values and the visual appearance of T2 mapping, including gradient T2, low T2, and high T2 patterns, were compared at the superior zones of the acetabular and femoral cartilages among the normal, pre-arthritic, and early-arthritic groups.Results: There were no significant differences in T2 values for both cartilages among the three groups. Regarding the visual appearance of T2 mapping for the acetabular cartilage, all hips in the normal group showed a gradient T2 pattern, while the pre-arthritic groups included six hips (43%) with a low T2 pattern, and the early-arthritic group showed either a low T2 pattern (33%) or a high T2 pattern (67%). The frequency of the gradient T2 pattern was significantly lower for dysplastic hips than for normal hips, in the acetabular and femoral cartilages (P < 0.05).Conclusions: This preliminary study demonstrated the clinical feasibility of T2 assessment of hip cartilage using 3 T MR imaging. T2 mapping classification may enable the early detection of osteoarthritic degeneration and the detection of developmental disorders of cartilage matrix in patients with hip dysplasia. (c) 2007 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.