Metabolomics as a tool in the identification of dietary biomarkers
Metabolomics as a tool in the identification of dietary biomarkers
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DOI：
10.1017/s002966511600032x
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发表时间：
2017-02-01
影响因子：
7
通讯作者：
Brennan, Lorraine
中科院分区：
文献类型：
--
作者：
Gibbons, Helena;Brennan, Lorraine
目前的膳食评估方法，包括FFQ，24小时召回和称重的食物日记与许多测量误差。为了克服这些错误，膳食生物标志物已经成为这些传统方法的补充方法。代谢组学已发展成为鉴定新的膳食生物标志物的关键技术，迄今为止，基于代谢组学的方法已导致鉴定许多推定的生物标志物。在饮食生物标志物发现中使用代谢组学时通常采用的三种方法是：（i）参与者消耗特定量的测试食物的急性干预，（ii）在特定食物的消费者和非消费者之间比较代谢谱的队列研究，以及（iii）分析饮食模式和代谢谱以识别营养类型和生物标志物。本综述批评了目前的文献中用于膳食生物标志物发现的方法，并给出了目前提出的生物标志物的详细概述，强调其充分验证所需的步骤。此外，本综述还评估了当前数据库和软件工具等领域，这些领域是推进结果解释所必需的，因此可以提高膳食生物标志物在营养研究中的实用性。
Current dietary assessment methods including FFQ, 24-h recalls and weighed food diaries are associated with many measurement errors. In an attempt to overcome some of these errors, dietary biomarkers have emerged as a complementary approach to these traditional methods. Metabolomics has developed as a key technology for the identification of new dietary biomarkers and to date, metabolomic-based approaches have led to the identification of a number of putative biomarkers. The three approaches generally employed when using metabolomics in dietary biomarker discovery are: (i) acute interventions where participants consume specific amounts of a test food, (ii) cohort studies where metabolic profiles are compared between consumers and non-consumers of a specific food and (iii) the analysis of dietary patterns and metabolic profiles to identify nutritypes and biomarkers. The present review critiques the current literature in terms of the approaches used for dietary biomarker discovery and gives a detailed overview of the currently proposed biomarkers, highlighting steps needed for their full validation. Furthermore, the present review also evaluates areas such as current databases and software tools, which are needed to advance the interpretation of results and therefore enhance the utility of dietary biomarkers in nutrition research.