Cognitive deficits 3 to 6 years before dementia onset in a population sample: the Honolulu-Asia aging study.
Cognitive deficits 3 to 6 years before dementia onset in a population sample: the Honolulu-Asia aging study.
复制标题
人口样本中痴呆症发病前 3 至 6 年的认知缺陷：檀香山-亚洲老龄化研究。
DOI：
10.1111/j.1532-5415.2005.53163.x
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发表时间：
2005
影响因子：
6.3
通讯作者：
White,LonR
中科院分区：
文献类型：
--
作者：
Jorm,AnthonyF;Masaki,KamalH;Petrovitch,Helen;Ross,GWebster;White,LonR
目的：确定人群样本中痴呆发作前3至6年发生的认知缺陷类型。设计：一项前瞻性研究，在基线和3年时检查6年随访时发生痴呆事件的参与者的认知缺陷。设置：檀香山，夏威夷。参与者：3734名基线时年龄为71至93岁的日裔美国男性。在6年的随访中，有52例痴呆事件，1，559例对照。测量：在基线时使用认知能力筛查工具（CASI）和主观记忆问题问卷。在基线以及3年和6年随访时对痴呆进行评估。结果：在6年随访时发生痴呆的受试者在3至6年前在CASI情景记忆领域和涵盖主观记忆问题的问卷中表现出缺陷。发病前3年，有恶化的情节记忆缺陷从基线和新的赤字在语言，语言流畅性，和orientation.Conclusion：认知缺陷和意识的记忆问题是经常出现几年前痴呆症发作。这些缺陷的预测值不足以早期诊断痴呆，但有关这些缺陷的信息可能是有用的轻度认知障碍的标准。
Objective:To determine the type of cognitive deficits occurring 3 to 6 years before onset of dementia in a population sample.Design:A prospective study in which cognitive deficits in participants who had incident dementia at the 6‐year follow‐up were examined at baseline and 3 years.Setting:Honolulu, Hawaii.Participants:Three thousand seven hundred thirty‐four Japanese‐American men aged 71 to 93 at baseline. At the 6‐year follow‐up, there were 52 incident cases of dementia, and 1,559 controls.Measurements:The Cognitive Abilities Screening Instrument (CASI) and a questionnaire on subjective memory problems were administered at baseline. Dementia was assessed at baseline and at 3‐year and 6‐year follow‐ups.Results:Subjects who had incident dementia at 6‐year follow‐up, had showed deficits 3 to 6 years earlier in the CASI domain of episodic memory and in the questionnaire covering subjective memory problems. Up to 3 years before onset, there was worsening of the episodic memory deficit from baseline and new deficits in language, verbal fluency, and orientation.Conclusion:Cognitive deficits and awareness of memory problems are frequently present several years before dementia onset. The predictive value of these deficits is not large enough to allow earlier diagnosis of dementia, but information about such deficits may be useful as criteria for mild cognitive impairment.