Phage-based Enzybiotics
Phage-based Enzybiotics
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DOI：
10.1079/9781845939847.0217
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发表时间：
2012-01-01
期刊：
影响因子：
--
通讯作者：
Nelson, Daniel C.
中科院分区：
文献类型：
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作者：
Shen, Yang;Mitchell, Michael S.;Nelson, Daniel C.
“酶生素”一词由 Vincent Fischetti 小组于 2001 年创造，用于描述噬菌体编码的内溶素的酶促特性和抗生素特性。近年来，一些作者将酶生学术语扩展为描述任何具有一般抗菌或抗真菌特性的酶，无论是否源自噬菌体。虽然酶生素最全面的定义包括所有内溶素、自溶素、外溶素以及可能的其他酶，但本章重点讨论噬菌体编码的酶，主要是内溶素。讨论了有关这些酶的作用机制、体外和体内（通常是小鼠模型）活性、与其他酶或抗生素的协同作用、免疫反应和对这些酶的耐药性的当前知识。最后部分简要回顾了细菌素和解聚酶，这是另外两类噬菌体编码的酶，也可能被视为酶生素。
The term'enzybiotic'was coined by Vincent Fischetti's group in 2001 to describe both the enzymatic and antibiotic properties of bacteriophage-encoded endolysins. In recent years, the enzybiotic term has been extended by some authors to describe any enzyme that displays general antibacterial or antifungal properties, whether phage-derived or not. While the most comprehensive definition of enzybiotics would include all endolysins, autolysins, exolysins and perhaps other enzymes, this chapter focuses on the phage-encoded enzymes, primarily the endolysins. Current knowledge about the mechanisms of action for these enzymes, in vitro and in vivo (usually mouse models) activity, synergy with other enzymes or antibiotics, immune responses and resistance to these enzymes, are discussed. The final sections briefly review bacteriocins and depolymerases, 2 other classes of phage-encoded enzymes that may also be considered enzybiotics.