Identification of α-Syntrophin Binding to Syntrophin Triplet, Dystrophin, and Utrophin (*)
Identification of α-Syntrophin Binding to Syntrophin Triplet, Dystrophin, and Utrophin (*)
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α-肌营养蛋白与肌营养蛋白三联体、肌营养不良蛋白和肌养蛋白结合的鉴定 (*)
DOI：
10.1074/jbc.270.10.4975
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
K. Campbell
中科院分区：
文献类型：
--
作者：
Bin Yang;D. Jung;J. Rafael;J. Chamberlain;K. Campbell
Syntrophin represents three cytoplasmic components of the dystrophin-glycoprotein complex that links the cytoskeleton to the extracellular matrix in skeletal muscle. α-Syntrophin has now been translated in vitro and shown to associate directly with all three components of the syntrophin triplet and with dystrophin. The in vitro translated 71-kDa non-muscle dystrophin isoform, containing the cysteine-rich/C-terminal domain, can also interact with the syntrophin triplet. The syntrophin binding motif in dystrophin was localized to exons 73 and 74 including amino acids 3447-3481 by comparing the interactions of α-syntrophin and seven overlapping human dystrophin fusion proteins. More than one syntrophin interaction site in this binding motif was suggested. α-Syntrophin also interacts directly with a C-terminal utrophin fusion protein. α-Syntrophin is localized to the muscle sarcolemma as well as to the neuromuscular junction in control mouse muscle. However, similar to utrophin, α-syntrophin is only present at the neuromuscular junction in mdx mouse muscle in which dystrophin is absent. Our data suggest that α-syntrophin binds all syntrophin isoforms, and syntrophin directly interacts with dystrophin through more than one binding site in dystrophin exons 73 and 74 including amino acids 3447-3481.
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影响因子：
3.5
作者：
RAFAEL, JA;SUNADA, Y;CHAMBERLAIN, JS
通讯作者：
CHAMBERLAIN, JS
肌营养不良蛋白和多种肌营养不良蛋白短形式与哺乳动物 M(r) 58,000 肌营养不良蛋白相关蛋白（肌营养不良蛋白）的关联。
DOI：
--
发表时间：
1994
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Kramarcy,NR;Vidal,A;Froehner,SC;Sealock,R
通讯作者：
Sealock,R
电组织的 Mr 58,000 突触后蛋白与鱼雷肌营养不良蛋白和 Mr 87,000 突触后蛋白的关联。
DOI：
--
发表时间：
1992
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Butler,MH;Douville,K;Murnane,AA;Kramarcy,NR;Cohen,JB;Sealock,R;Froehner,SC
通讯作者：
Froehner,SC
影响因子：
3.5
作者：
Tonini, R;Franceschetti, S;Zippel, R
通讯作者：
Zippel, R
DOI：
10.1073/pnas.91.10.4446
发表时间：
1994-05-10
影响因子：
11.1
作者：
AHN, AH;YOSHIDA, M;KUNKEL, LM
通讯作者：
KUNKEL, LM