Total synthesis of the anthelmintic agent hikizimycin
Total synthesis of the anthelmintic agent hikizimycin
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驱虫剂Hikizimycin的全合成
DOI：
10.1021/ja00182a045
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发表时间：
1990
影响因子：
15
通讯作者：
S. Schreiber
中科院分区：
文献类型：
--
作者：
N. Ikemoto;S. Schreiber
从链霉菌A-5 ′的发酵液中分离出一种与从长链霉菌中分离出的安泰尔霉素相同的Hikizimycin。1.2生物化学研究表明，hikizimycin对多种常见寄生虫具有显著的驱虫活性。3降解研究4鉴定出存在胞嘧啶碱基、3-氨基-3-脱氧葡萄糖（卡那糖胺）和4-氨基十一碳糖（hikosamine）。最终，提出了hikizimycin的结构，如图1所示，5在此，我们报告了第一个总的
Hikizimycin was isolated from the fermentation broth of Streptomyces A-5'and was determined to be identical with an-thelmycin, which was isolated from Streptomyces longissimus. 1 2 Biochemical studies of hikizimycin revealed significant anthel-mintic activity against a variety of common parasites. 3 Degradation studies4 identified the presence of a cytosine base, a 3-amino-3-deoxyglucose sugar (kanosamine), and a 4-aminoundecose sugar (hikosamine). Eventually, the structure of hikizimycin was proposed as shown in Figure 1, 5 Herein, we report the first total