Maternal Sedentary Behavior and Physical Activity across Pregnancy and Early Childhood Growth.
Maternal Sedentary Behavior and Physical Activity across Pregnancy and Early Childhood Growth.
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怀孕期间和儿童早期成长过程中母亲的久坐行为和体力活动。
DOI：
10.1089/chi.2021.0202
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Gibbs,BethanyBarone
中科院分区：
文献类型：
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作者：
Jones,MelissaA;Whitaker,Kara;TavernoRoss,SharonE;Davis,Kelliann;Libertus,Klaus;Gibbs,BethanyBarone
背景：子宫暴露的证据与后代的终身健康有关。无论是母亲在怀孕期间的活动配置文件影响后代health.Methods：这项后续研究招募母亲客观测量久坐行为（SED）和中度到剧烈强度的体力活动（MVPA）从以前的队列研究。在整个妊娠期（轨迹组）和连续三个月分析母体活动。从病历中提取了24个月的后代人体测量数据（n= 62）。结果包括儿童期生长率（24个月内BMI z评分变化的递增率）和快速生长（12个月时BMI z评分增加>0.67）。产妇活动与增长率的关联进行了检查，使用混合线性模型和快速增长，使用广义线性models.Results：百分之四十的参与者在高SED和20%的高MVPA轨迹在怀孕期间。整个妊娠期[斜率（95%置信区间; CI）：0.080（0.024-0.061）Δ BMI z评分/月]和妊娠早期[标准化β; stdβ（95% CI）：0.017（0.007-0.026）]的较高SED与加速生长率相关。妊娠中期和妊娠晚期较高的MVPA与生长速度加快相关[标准β（95%CI）：妊娠2期：0.013（0.002-0.024）和三个月：0.011（0.003-0.020）]和快速生长的风险更大[风险比（95%CI）：妊娠2期：1.25（1.009-1.555）和孕3期：1.25（1.056-1.475）]。结论：这些发现增加了越来越多的证据表明，妊娠期间高SED的有害影响。MVPA越高，加速增长的风险越大，这引发了进一步的调查。总体而言，孕产妇活动概况显示，作为一种可改变的行为，以改善代际健康的承诺。
Background:Evidence suggestsin uteroexposures are related to lifespan health of the offspring. Whether maternal activity profile during pregnancy impacts offspring health remains unknown.Methods:This follow-up study recruited mothers with objectively measured sedentary behavior (SED) and moderate-to-vigorous intensity physical activity (MVPA) from a previous cohort study. Maternal activity was analyzed across pregnancy (trajectory groups) and continuously by trimester. Offspring anthropometrics up to 24 months were abstracted from medical records (n= 62). Outcomes included childhood growth rate (incremental rate of BMIz-score change up to 24 months) and rapid growth (increased BMIz-score >0.67 at 12 months). Associations of maternal activity with growth rate were examined using mixed linear models and rapid growth using generalized linear models.Results:Forty percent of participants were in the high SED and 20% in the high MVPA trajectories during pregnancy. Higher SED, across pregnancy [slope (95% confidence interval; CI): 0.080 (0.024–0.061) ΔBMIz-score/month] and in the first trimester [standardized beta; stdβ(95% CI): 0.017 (0.007–0.026)], was related to accelerated growth rate. Higher MVPA, in the second and third trimesters, was associated with accelerated growth rate [stdβ(95% CI): trimester 2: 0.013 (0.002–0.024) and trimester 3:0.011 (0.003–0.020)] and greater risk of rapid growth [risk ratio (95% CI): trimester 2: 1.25 (1.009–1.555) and trimester 3: 1.25 (1.056–1.475)].Conclusions:These findings add to growing evidence on the deleterious effects of high SED during pregnancy. The increased risk for accelerated growth with higher MVPA elicits further investigation. Overall, maternal activity profile shows promise as a modifiable behavior to improve intergenerational health.